Abstract
The effects of some cannabinoid-related analgesics were examined in squirrel monkeys responding under a schedule of shock titration. Nantradol (0.1–0.3 mg/kg), levonantradol (0.03–0.1 mg/kg), or N-metnyl levonantradol (0.01–0.03 mg/kg) increased the level at which shock was maintained, but did not change rates of responding. Nantradol effects were not blocked by naloxone (0.3–3.0 mg/kg), but they were attenuated following daily administration of nantradol.
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References
Dykstra LA (1981) Effects of morphine, levonantradol, and N-methyl-levonantradol on shock intensity discrimination. J Clin Pharmacol 21:341–347
Dykstra LA (1979) Effects of morphine, pentazocine and cyclazocine, alone and in combination with naloxone, on electric shock titration in the squirrel monkey. J Pharmacol Exp Ther 211:722–732
Gilbert PE (1981) A comparison of THC, nantradol, nabilone, and morphine in the chronic spinal dog. J Clin Pharmacol 21:311–319
Jacob JJ, Ramabadran K, Campso-Medeiros M (1981) A pharmacological analysis of levonantradol antinociception in mice. J Clin Pharmacol 21:327–333
Jain AK, Ryan JR, McMahon F, Smith G (1981) Evaluation of intramuscular levonantradol and placebo in acute postoperative pain. J Clin Pharmacol 21:320–326
Lal H, Bennett DA, Shearman GT, McCarten MD, Murphy R and Angeja A (1981) Effectiveness of nantradol in blocking narcotic withdrawal signs through nonnarcotic mechanisms. J Clin Pharmacol 21:361–366
McIlhenny HM, Mast RW, Johnson MR, Milne GM (1981) Nantradol hydrochloride: Pharmacokinetics and behavioral effects after acute and chronic treatment. J Pharmacol Exp Ther 219:363–369
Milne GM, Koe BK, Johnson MR (1980a) Stereospecific and potent analgetic activity for nantradol: A structurally novel, cannabinoid-related analgetic. Natl Inst Drug Abuse Res Monogr Ser 27:84–92
Milne GM, McIlhenny HM, Johnson MR, Koe BK, Weissman A (1980b) One-way cross-tolerance from morphine to nantradol: a potent nonopioid analgetic. In: Way LE (ed) Endogenous and exogenous opiate agonists and antagonists. Pergamon, New York, pp 367–370
Yaksh RL (1981) The antinociceptive effects of intrathecally administered levonantradol and desacetyllevonantradol in the rat. J Clin Pharmacol 21:334–340
Young AM, Katz JL, Woods JH (1981) Behavioral effects of levonantradol and nantradol in the rhesus monkey. J Clin Pharmacol 21:348–360
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Dykstra, L.A. Electric shock titration in squirrel monkeys following administration of nantradol, levonantradol, or N-Methyl levonantradol. Psychopharmacology 79, 322–324 (1983). https://doi.org/10.1007/BF00433410
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DOI: https://doi.org/10.1007/BF00433410