Summary
The intrarenal SNGFR distribution was examined in rats undergoing extracellular fluid volume expansion using 1.14C ferrocyanide infusion technique, 2. Hanssen's technique, 3. Hanssen's technique after infusion of unlabelled ferrocyanide solution. The S/JM SNGFR ratios were respectively 0.74±0.12 S.D., 0.98±0.12 S.D., 0.95±0.12 S.D. in the three groups. Thus no SNGFR redistribution was found using the14C ferrocyanide infusion technique. In contrast, redistribution was observed using Hanssen's technique, both in the presence and absence of a previous ferrocyanide infusion. It was concluded that the presence of ferrocyanide ions at the macula densa site does not influence intrarenal SNGFR distribution. The authors suggest that the redistribution observed using Hanssen's technique results from the method used to inject the label.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Baines, A. D., with the technical assistance of Bishop, J. V. H.: Effect of extracellular fluid volume expansion on maximum glucose reabsorption rate and glomerulo-tubular balance in single rat nephrons. J. clin. Invest.50, 2414 (1971)
Baines, A. D.: SNGFR redistribution: a structurally determined phenomenon in young rats. 5th Inter. cong. Nephrol., Mexico (Abstr.) p. 70 (1972)
Baines, A. D., with the technical assistance of Godi, I.: Redistribution of nephron function in response to chronic and acute solute loads. Amer. J. Physiol.224, 237 (1973)
Bencsàth, P., Bonvalet, J. P., Rouffignac, C. de: Tubular factors in denervation diuresis and natriuresis, in Recent advances in renal physiology. International Symposium on renal handling of sodium (Brestenberg), p. 96. Basel: S. Karger 1972
Bonvalet, J. P., Bencsàth, P., Rouffignac, C. de, with the technical assistance of Deiss, S.: Glomerular filtration rate of superficial and deep nephrons during aortic constriction. Amer. J. Physiol.222, 599 (1972)
Bray, G. A.: A simple efficient liquid scintillator for counting aqueous solutions in a liquid scintillation counter. Analyt. Biochem.1, 179 (1960)
Chabardès, D., Poujeol, P., Bencsàth, P., Bonvalet, J. P., Rouffignac, C. de (avec la collaboration technique de Deiss, S.): Distribution intrarénale des filtrations glomérulaires individuelles au cours d'une surcharge sodée. Nouvelles données obtenues par la technique de perfusion de ferrocyanure. J. Physiol. (Paris)65, 374 A (1972)
Coelho, J. B., Bradley, S. E.: Role of a redistribution of single glomerular filtration rate (SNGFR) in sodium excretion. 5th Inter. cong. Nephrol., Mexico (Abstr.) p. 89 (1972)
Coelho, J. B., Chien, K. C. H., Bradley, S. E.: Measurement of single nephron glomerular filtration rate without micropuncture. Amer. J. Physiol.223, 832 (1972)
Coelho, J. B., Chien, K. C. H., Stella, S. R., Bradley, S. E.: Relationship of extraluminal tubular deposition of ferrocyanide to peritubular perfusion rate in cortical and medullary nephron segments of the rat kidney. Circulat. Res.29, 21 (1971)
Coelho, J. B., Stella, S. R., Chien, K. C. H., Bradley, S. E.: Glomerular filtration rate in superficial and juxtamedullary nephrons during salt loading and hemorrhagic hypotension (Abstr.). Clin. Res.18, 496 (1970)
Davis, J. M., Schnermann, J.: The effect of antidiuretic hormone on the distribution of nephron filtration rates in rats with hereditary diabetes insipidus. Pflügers Arch.330, 323 (1971)
Guyton, A. C.: Theory for autoregulation of glomerular filtration rate and blood flow in each nephron by the juxtaglomerular apparatus. Physiologist6, 194 (1963)
Hanssen, O. E.: Method for comparison of glomerular filtration in individual rat nephrons. 2nd Int. cong. Nephrol., Prague, p. 527 (1963)
Lassiter, W. E., Mylle, M., Gottschalk, C. W.: Net transtubular movement of water and urea in saline diuresis. Amer. J. Physiol.206, 669 (1964)
Moss, N. G., Rouffignac, C. de: Comparison between the renal handling of14C. Na ferrocyanide and3H-methoxy inulin in the rat. Pflügers Arch.338, 19 (1972)
Poujeol, P., Chabardès, D., Bonvalet, J. P., Rouffignac, C. de (avec la collaboration technique de Deiss, S.): Microsphères: nouvelle technique d'utilisation pour l'étude de la distribution intracorticale du flux sanguin rénal. Résultats chez le rat normal et surchargé en sodium. J. Physiol. (Paris)65, 481 A (1972)
Rouffignac, C. de, Bonvalet, J. P.: Étude chez le rat des variations du débit individuel de filtration glomérulaire des néphrons superficiels et profonds en fonction de l'apport sodé. Pflügers Arch.317, 141 (1970)
Rouffignac, C. de, Bonvalet, J. P., Menard, J.: Radioimmunoassay of renin conent in superficial and deep glomeruli of normal salt loaded rats. Amer. J. Physiol.226, 150 (1974)
Rouffignac, C. de, Deiss, S., Bonvalet, J. P.: Détermination du taux individuel de filtration glomérulaire des néphrons accessible et inaccessible à la microponction. Pflügers Arch.315, 273 (1970)
Rouffignac, C. de, Morel, F. (avec la collaboration technique de Deiss, S.): Etude par microdissection de la distribution et de la longuer des tubules proximaux dans le rein de cinq espèces de rongeurs. Arch. Anat. micr. Morph. exp.56, 123 (1968)
Scott Blair, G. W.: Flow of complex systems through capillaries. In: Elementary rheology, p. 25. London-New York: Academic Press 1969
Thurau, K.: Renal hemodynamics. Amer. J. Med.36, 698 (1964)
Thurau, K.: Enzymes of the juxtaglomerular apparatus: activation of renin by NaCl in the Macula Densa segment of the nephron. In: Biochemical aspects of kidney function, p. 203, M. Hohenegger, ed. München 1972
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Chabardès, D., Poujeol, P., Deiss, S. et al. Intrarenal glomerular filtration rate distribution in salt loaded rats. Pflugers Arch. 349, 191–202 (1974). https://doi.org/10.1007/BF00592447
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00592447