Summary
Experiments were carried out on pentobarbital-anaesthetized dogs previously subjected to unilateral splanchnicotomy. Renal blood flow (RBF), glomerular filtration rate (GFR), tubular reabsorption of sodium (TRFNa), and oxygen consumption (Q O 2) were determined in normal state, following isotonic volume expansion and during furosemide administration (0.5–1.5 mg/kg bw.). Denervation diuresis and natriuresis occurred under all experimental conditions. TRFNa/Q O 2 was 31.4 mEq/mMol for intact and 27.7 mEq/mMol for denervated kidneys in the normal and isotonic volume expanded dogs. These values decreased significantly to 16.8 mEq/mMol and 18.3 mEq/mMol, respectively, upon furosemide loading. No difference between intact and denervated kidneys was observed in either group. TRFNa, RBF, and GFR were significantly correlated toQ O 2 with no difference between intact and splanchnicotomized sides. An inhibitory effect of renal denervation on active sodium transport in the proximal tubule is suggested.
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References
Bálint, P., Forgács, I.: Sauerstoffverbrauch der Niere in verschiedenen experimentellen Zuständen. Pflügers Arch. ges. Physiol.277, 558–569 (1963)
Bálint, P., Forgács, I.: Natriumreabsorption und Sauerstoffverbrauch der Niere bei osmotischer Belastung. Pflügers Arch. ges. Physiol.288, 332–341 (1966)
Bencsáth, P., Takács, L.: Intrarenal distribution of blood flow and cortico-medullary sodium gradient after unilateral splanchnicotomy in the dog. J, Physiol. (London)212, 629–640 (1971)
Bencsáth, P., Bonvalet, J. P., de Rouffignac, C.: Tubular factors in denervation diuresis and natriuresis. Recent advances in renal physiology. Int. Symp. on renal handling of sodium, Brestenberg 1971, pp. 96–106. Basel: Karger 1972
Blake, W. D., Jurf, A. N.: Renal sodium reabsorption after acute renal denervation in the rabbit. J. Physiol. (Lond.)196, 65–73 (1968)
Bonjour, J. P., Churchill, P. C., Malvin, R. L.: Change of tubular reabsorption of sodium and water after renervation in the dog. J. Physiol. (Lond.)204, 571–582 (1969)
Bratton, A. C., Marshall, E. K.: A new coupling component for sulfanilamide determination. J. biol. Chem.128, 537–550 (1939)
Deetjen, P., Kramer, K.: Die Abhängigkeit des O2-Verbrauches der Niere von der Natriumrückresorption. Pflügers Arch. ges. Physiol.273, 636–650 (1961)
Fujimoto, M., Nash, J. D., Kessler, R. H.: Effects of cyanide,Q O, and dinitrophenol on renal sodium reabsorption and oxygen consumption. Amer. J. Physiol.206, 1327–1332 (1964)
Fülgraff, G., Wolf, K., Adelmann, J., Krieger, A.-K.: Zum Wirkungsmechanismus von Diuretica. Die Wirkung von Furosemid auf den O2-Verbrauch der Niere. Naunyn-Schmiedebergs Arch. Pharmak. exp. Path.263, 485–495 (1969)
Harrison, H. E.: A modification of the diphenylamine method for determination of inulin. Proc. Soc. exp. Biol. (N. Y.)49, 111–114 (1942)
Holmes, E. W., Jr., DiScala, V. A.: Studies on the exaggerated natriuretic response to a saline infusion in the hypothyroid. J. clin. Invest.49, 1224–1236 (1970)
Holmes, E. W., Jr., DiScala, V. A.: Oxygen consumption, glycolysis, and sodium reabsorption in the hypothyroid rat kidney. Amer. J. Physiol.221, 839–843 (1971)
Kiil, F., Aukland, F., Refsum, H. E.: Renal sodium transport and oxygen consumption. Amer. J. Physiol.201, 511–516 (1961)
Knox, F. G., Fleming, J. S., Rennie, D. W.: Effects of osmotic diuresis on sodium reabsorption and oxygen consumption of the kidney. Amer. J. Physiol.210, 751–759 (1966)
Kramer, K., Deetjen, P.: Beziehungen des O2-Verbrauchs der Niere zu Durchblutung und Glomerulumfiltrat bei Änderung des arteriellen Druckes. Pflügers Arch. ges. Physiol.271, 782–796 (1960)
Lassen, N. A., Munck, O., Thaysen, J. H.: Oxygen consumption and sodium reabsorption in the kidney. Acta physiol. scand.51, 371–384 (1961)
Ofstad, J., Willassen, Y., Gjengstø, H.: The effect of furosemide upon oxygen consumption in the human kidney. Acta med. scand.192, 95–97 (1972)
Takács, L., Bencsáth, P., Demeczky, L.: Renal sodium and water excretion after unilateral splanchnicotomy in the dog. Acta Physiol. Acad. Sci. hung.39, 283–291 (1971)
Thurau, K.: Renal Na-reabsorption and O2-uptake in dogs during hypoxia and hydrochlorothiazide infusion. Proc. Soc. exp. Biol. (N.Y.)106, 714–717 (1961)
Torelli, G., Milla, E., Faelli, A., Constantini, S.: Energy requirement for sodium reabsorption in the in vivo rabbit kidney. Amer. J. Physiol.211, 576–581 (1966)
Trimble, M. E., Bowman, R. H.: Oxygen consumption and sodium transport in the isolated perfused rat kidney. Fed. Proc.31, 721 (1972)
Weiner, J. M., Roth, L., Skulan, T. W.: Effect of dinitrophenol and cyanide on TPAH and Na reabsorption. Amer. J. Physiol.221, 86–91 (1971)
Weinstein, S. W.: Proximal tubular energy metabolism, sodium transport, and permeability in the rat. Amer. J. Physiol.219, 978–981 (1970)
Weinstein, S. W., Klose, R. M.: Micropuncture studies on energy metabolism and sodium transport in the mammalian nephron. Amer. J. Physiol.217, 498–504 (1969)
Windhager, E. E., Giebisch, G.: Comparison of shortcircuit current and net water movement in single perfused proximal tubules of rat kidneys. Nature (Lond.)191, 1205–1206 (1961)
Wolf, K., Bieg, A., Fülgraff, F.: On the mode of action of diuretics. II. Effects of ethacrynic acid on renal oxygen consumption and tubular sodium reabsorption in dogs. Europ. J. Pharmacol.7, 342–344 (1969)
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Szalay, L., Bencsáth, P. & Takács, L. Renal sodium reabsorption and oxygen consumption after unilateral splanchnicotomy in the dog. Pflugers Arch. 349, 359–367 (1974). https://doi.org/10.1007/BF00588421
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DOI: https://doi.org/10.1007/BF00588421