Abstract
Lungs from seven healthy female, sea level rats were perfused and ventilated in vitro. Hypoxic pulmonary vasoconstriction was stimulated by changing the inspired gas from 21% oxygen to 6, 4, 3 or 0% oxygen (all gases contained 5% carbon dioxide and balance nitrogen). A sigmoid stimulus-response curve was derived by probit analysis with a 50% of maximum response (ED50) at an oxygen tension of 3.49±0.17 kPa. It is suggested that such characterizations of the response to hypoxia may allow a more precise comparison of the effects of species, age, sex and drugs on hypoxic pulmonary vasoconstriction.
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References
Barer GR, Howard P, Shaw JW (1970) Stimulus-response curves for the pulmonary vascular bed to hypoxia and hypercapnia. J Physiol (Lond) 211:139–155
Benumof JL, Wahrenbrock EA (1975) Blunted hypoxic pulmonary vasoconstriction by increased lung vascular pressure. J Appl Physiol 38:846–850
Finney DJ (1952) Probit analysis, Cambridge University Press, 2nd ed, pp 183–198
Fishman AP (1976) Hypoxia on the pulmonary circulation. How and where it acts. Circ Res 38:221–231
Grant BJB, Davies EE, Jones HA, Hughes JMB (1976) Local regulation of pulmonary blood flow and ventilation-perfusion ratios in the coati mundi. J Appl Physiol 40:216–228
Hauge A (1969) Hypoxia and pulmonary vascular resistance. The relative effects of pulmonary arterial and alveolarP O 2. Acta Physiol Scand 76, 121–130
Lloyd TC (1983) Relationship between vascular resistance and venous pressure (Letter to Editor). J Appl Physiol 54:321
Marshall BE, Marshall C (1980) Continuity of response to hypoxic pulmonary vasoconstriction. J Appl Physiol 49:189–196
Marshall BE, Marshall C, Benumof J, Saidman LR (1981) Hypoxic pulmonary vasoconstriction in dogs: effects of lung segment size and oxygen tension. J Appl Physiol 51:1543–1551
McMurtry IF, Frith CH, Will DH (1973) Cardiopulmonary responses of male and female swine to simulated high altitude. J Appl Physiol 35:459–462
McMurtry IF, Petrum MD, Reeves JT (1978) Lungs from chronically hypoxic rats have decreased pressor response to acute hypoxia. Am J Physiol 235:H104–109
Rendas A, Branthwaite M, Lennox S, Reid L (1982) Response of the pulmonary circulation to acute hypoxia in the growing pig. J Appl Physiol 52:811–814
Sylvester JT, Harabin AL, Peake MD, Frank RS (1980) Vasodilator and constrictor responses to hypoxia in isolated pig lungs. J Appl Physiol 49:820–825
Tucker A, Rodeghero PT (1981) Vascular responsiveness in isolated rat lungs is inversely related to blood flow. Respiration 42:228–232
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Marshall, C., Marshall, B.E. Characterization of the stimulus-response curve for hypoxic pulmonary vasoconstriction. Pflugers Arch. 398, 93–95 (1983). https://doi.org/10.1007/BF00581054
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DOI: https://doi.org/10.1007/BF00581054