Abstract
Conscious, chronically instrumented dogs, maintained on a high sodium intake, were used to investigate whether surgical cardiac denervation impairs the natriuresis associated with left atrial pressure increase produced in three ways: during an increase in left atrial pressure by means of a reversible mitral stenosis (protocol 1); after an i.v. saline load (1.0 ml 0.9%·saline min−1·kg−1 over 60 min) (protocol 2); after an oral saline load (14.5 mmol Na·kg−1 given with the food as an isotonic solution) (protocol 3).
During a reversible mitral stenosis, in intact dogs, urine volume and sodium excretion increased markedly (from 34–145 μl·min−1·kg−1 and from 3–12 μmol·min−1·kg−1); mean arterial pressure increased by an average of 2 kPa (15 mm Hg) and heart rate by 55 b/min; plasma renin activity fell from 0.37–0.21 ng Al·ml−1·h−1. Cardiac denervation eliminated these effects of left atrial distension except for a small increase in heart rate (12 b/min). This indicates that the natriuresis and diuresis during left atrial distension resulted from stimulation of receptors located in the left atrium.
In contrast, during protocol 2 and 3, the same amounts of sodium and water were excreted in the cardiac denervated dogs as compared to the intact dogs. A comparable decrease in plasma renin activity also was observed. — Apparently the presence of the cardiac nerves is not a prerequisite for maintenance of sodium and water homeostasis.
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References
Behrenbeck DW, Reinhardt HW (1967) Untersuchungen an wachen Hunden über die Einstellung der Natriumbilanz. II. Postprandiale Elektrolyt- und Wasserbilanz bei unterschiedlicher Kochsalzzufuhr. Pflügers Arch Ges Physiol 295:280–292
Drake AJ, Stubbs J, Noble MIM (1978) Dependence of myocardial blood flow and metabolism on cardiac innervation. Cardiovasc Res 12:69–80
Fater DC, Sundet WD, Schultz HD, Goetz KL (1980) Cardiac denervation eliminates the diuretic response elicited by increasing left atrial pressure with a balloon. Fed Proc 39:3592 (Abstract)
Gauer OH, Henry JP (1976) Neurohormonal control of plasma volume. Int Rev Physiol Cardiovasc Physiol II 9:145–190
Gilmore JP, Daggett WM (1966) Response of the chronic cardiac denervated dog to acute volume expansion. Am J Physiol 210:509–512
Goetz KL, Bond GC, Bloxham DD (1975) Atrial receptors and renal function. Physiol Rev 55:157–205
Guyton AC (1976) Regulation of arterial pressure: II. The renal-body fluid system for long-term pressure control. The mechanisms of hypertension. In: Guyton AC (ed) Textbook of medical physiology, chapter 22. WB Saunders Comp, Philadelphia London Toronto, pp 279–294
Haber E, Koerner T, Page LB, Kliman B, Purnode A (1969) Application of a radioimmunoassay for angiotensin I to the physiologie measurements of plasma renin activity in normal human subjects. J Clin Endocr 29:1349–1355
Henry JO, Pearce JW (1956) The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow. J Physiol 131:572–585
Johnson JA, Moore WW, Segar WE (1969) Small changes in left atrial pressure and plasma antidiuretic hormone titers in dogs. Am J Physiol 217:210–214
Johnson MD, Malvin RL (1977) Stimulation of renal sodium reabsorption by angiotensin II. Am J Physiol 232:F298–306
Kaczmarczyk G, Eigenheer F, Gatzka M, Kuhl U, Reinhardt HW (1978) No relation between atrial natriuresis and renal blood flow in conscious dogs. Pflügers Arch 373:49–58
Kaczmarczyk G, Mohnhaupt R, Simgen B, Reinhardt HW (1980) Postprandial (pp) volume regulation and renin-angiotensin system (RAS) in conscious dogs. Proc Int Union Physiol Sci 14:0327
Kaczmarczyk G, Schimmrich B, Mohnhaupt R, Reinhardt HW (1979) Atrial pressure and postprandial volume regulation in conscious dogs. Pflügers Arch 381:143–150
Kaczmarczyk G, Unger V, Mohnhaupt R, Reinhardt HW (1981) Left atrial distension and intrarenal blood flow distribution in conscious dogs. Pflügers Arch 390:44–48
Keck W, Brechtelsbauer H, Kramer K (1969) Wasser- und Natriumausscheidung nach isotonen Kochsalz-Infusionen bei wachen Hunden mit verschiedenem Natriumbestand. Pflügers Arch 311:119–130
Keck W, Joppich R, v Restorff WD, Finsterer U, Prucksunand P, Brechtelsbauer H, Kramer K (1973) Sodium excretion in conscious and anesthetized dogs after large saline infusions. Pflügers Arch 341:51–62
Knox FG, Davis BB, Berliner RW (1967) Effect of chronic cardiac denervation on renal response to saline infusion. Am J Physiol 213:174–178
Lydtin H, Hamilton WF (1964) Effect of acute changes in left atrial pressure on urine flow in unanesthetized dogs. Am J Physiol 207:530–536
McDonald KM, Rosenthal A, Schrier RW, Galicich J, Lauler DP (1970) Effect of interruption of neutral pathways on renal response to volume expansion. Am J Physiol 218:510–517
Reinhardt HW, Behrenbeck DW (1967) Untersuchungen an wachen Hunden über die Einstellung der Natriumbilanz. I. Die Bedeutung des Extracellulärraumes für die Einstellung der Natrium-Tagesbilanz. Pflügers Arch Ges Physiol 295:266–279
Reinhardt HW, Eisele R, Kaczmarczyk G, Mohnhaupt R, Oelkers W, Schimmrich B (1980a) The control of sodium excretion by reflexes from the low pressure system independent of adrenal activity. Pflügers Arch 384:171–176
Reinhardt HW, Kaczmarczyk G, Eisele R, Eigenheer F, Kuhl U (1977) Left atrial pressure and sodium balance in conscious dogs on a low sodium intake. Pflügers Arch 370:59–66
Reinhardt HW, Kaczmarczyk G, Mohnhaupt R, Simgen B (1980b) Atrial natriuresis under the condition of a constant renal perfusion pressure — Experiments on conscious dogs — Pflügers Arch 389:9–15
Thoren P (1979) Role of cardiac vagal c-fibers in cardiovascular control. Rev Physiol Biochem Pharmacol 86:1–94
Wegener S, Kaczmarczyk G, Schimmrich B, Mohnhaupt R, Reinhardt HW (1978) Suppression of atrial natriuresis after acute and chronic reduction of total body sodium (TBS). Experiments on conscious dogs on a high or a low sodium intake. Pflügers Arch Suppl 377:60
Wiberg I, Vaage J, Scott E (1979) Release of prostaglandin-like substances during elevations of left atrial pressure in the cat. Acta Physiol Scand 107:97–103
Zehr JE, Hasbargen JA, Kurz KD (1976) Reflex suppression of renin secretion during distension of cardiopulmonary receptors in dogs. Circ Res 38:232–239
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Kaczmarczyk, G., Drake, A., Eisele, R. et al. The role of the cardiac nerves in the regulation of sodium excretion in conscious dogs. Pflugers Arch. 390, 125–130 (1981). https://doi.org/10.1007/BF00590194
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DOI: https://doi.org/10.1007/BF00590194