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Rat insulinoma cell line used as target for detection of islet cell surface antibodies in type I diabetics

Ratteninsulinom-Zellinie als Target für den Nachweis von Inselzelloberflächenantikörpern bei Typ -I-Diabetikern

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  • Immunological Analysis
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Conclusion

The rat insulinoma line RIN-5AH-T2 has several advantages over the normal rat islet cells to detect ICSA:1. The RIN cell population is homogenous, whereas PRI cells contain other cell types in addition to B-cells; 2. large quantities of RIN cells can be easily prepared; 3. the rat insulinoma line should make it possible to compare more readily results from different laboratories.

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References

  1. Bottazzo GF (1984) Diabetologia 26:241

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Authors and Affiliations

  1. Central Institute of Diabetes, Greifswalder Str. 11a, DDR-2201, Karlsburg, German Democratic Republic

    M. Ziegler, W. Hildmann, Brigitte Ziegler & D. Michaelis

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  1. M. Ziegler
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  2. W. Hildmann
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  3. Brigitte Ziegler
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  4. D. Michaelis
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Ziegler, M., Hildmann, W., Ziegler, B. et al. Rat insulinoma cell line used as target for detection of islet cell surface antibodies in type I diabetics. Z. Anal. Chem. 324, 252–253 (1986). https://doi.org/10.1007/BF00487898

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  • DOI: https://doi.org/10.1007/BF00487898

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