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Use of ultrasonic nebulizer with desolvator membrane for the determination of titanium and zirconium in human serum by means of inductively coupled plasma – mass spectroscopy

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Abstract

A technique for the determination of titanium and zirconium in human blood serum, after pressurized digestion utilizing ICP-MS coupled to an ultrasonic nebulizer (USN) and desolvating membrane is described. As no CRM for titanium is available, zirconium has been determined in order to demonstrate the accuracy of the technique, as the limits in blood are well known. Bone cement consists basically of a polymer, namely polymethylmethacrylate (PMMA). For better X-ray contrast some manufacturers use incorporated ZrO2 with a volume fraction of 10 to 15%. Thus, the zirconium present in the PMMA matrix can be used as an indicator for the PMMA particulate debris.

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Authors and Affiliations

  1. Central Laboratory of Analytical Chemistry, Technical University Hamburg-Harburg, Eißendorfer Strasse 38, D-21073 Hamburg, Germany, , , , , , DE

    J. Kunze, S. Koelling & M. Reich

  2. Technical University Hamburg-Harburg, Biomechanics Section, Harburger Schloßstrasse 36, D-21079 Hamburg, Germany, , , , , , DE

    M. A. Wimmer

Authors
  1. J. Kunze
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  2. S. Koelling
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  3. M. Reich
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  4. M. A. Wimmer
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Received: 26 April 1999 / Revised: 24 June 1999 / /Accepted: 7 July 1999

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Kunze, J., Koelling, S., Reich, M. et al. Use of ultrasonic nebulizer with desolvator membrane for the determination of titanium and zirconium in human serum by means of inductively coupled plasma – mass spectroscopy. Fresenius J Anal Chem 366, 165–166 (2000). https://doi.org/10.1007/s002160050031

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  • DOI: https://doi.org/10.1007/s002160050031

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