Summary
In anaesthetized cats, electric pulse stimuli were applied at various lateralities to the anterior lobe of the cerebellum. In dorsal Deiters neurones delayed IPSPs with latencies of 3–6 msec were evoked from the entire area of the culmen including the paravermis bilaterally. The delayed IPSPs had a summit time of about 2 msec and a duration of about 7 msec. They showed a marked temporal facilitation and subsequent depression with double shock stimulation. Corticovestibular fibers were penetrated within the nucleus of Deiters and showed delayed, labile responses to cortical stimulation, corresponding to the delayed IPSPs in Deiters neurones. During stimulation of the anterior lobe at any laterality, field potentials recorded in the cerebellar cortex further revealed that there was activation, presumably through axon collaterals of mossy fibers, of granule cells and subsequently of Purkinje cells in the vermal cortex. Cortical events exhibited a prominent temporal facilitation and subsequent depression, in parallel with that observed for the delayed IPSPs in Deiters neurones. The delayed IPSPs in Deiters neurones arising from a wide area of the cerebellar cortex thus were attributed to activation through mossy fiber-granule cell pathway of Purkinje cells of the corticovestibular projection.
Similar content being viewed by others
References
Anderson, P., Eccles, J.C., Voorhoeve, P.E.: Postsynaptic inhibition of cerebellar Purkinje cells. J. Neurophysiol. 27, 1138–1153 (1964).
Armstrong, D.M., Harvey, R.J., Schild, R.F.: Branching of individual olivo-cerebellar axons to terminate in more than one subdivision of the feline cerebellar cortex. J. Physiol. (Lond.) 202, 106P-108P (1969).
Brodal, A.: Experimentelle Untersuchungen über die olivo-cerebellare Lokalisation. Z. ges. Neurol. Psychiat. 169, 1–153 (1940).
Dow, R.S.: Action potentials of cerebellar cortex in response to local electrical stimulation. J. Neurophysiol. 12, 245–256 (1949).
Eager, R.: Efferent cortico-nuclear pathways in the cerebellum of the cat. J. comp. Neurol. 120, 81–104 (1963).
Eccles, J.C., Ito, M., Szentágothai, J.: The Cerebellum as a Neuronal Machine. Berlin-Heidelberg-New York: Springer 1967.
—, Llinás, R., Sasaki, K.: The inhibitory interneurones within the cerebellar cortex. Exp. Brain Res. 1, 1–16 (1966a).
—: Parallel fiber stimulation and the responses induced thereby in the Purkinje cells of the cerebellum. Exp. Brain Res. 1, 17–39 (1966b).
—: The mossy fiber-granule cell relay in the cerebellum and its inhibition by Golgi cells. Exp. Brain Res. 1, 82–101 (1966c).
—: The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum. J. Physiol. (Lond.) 182, 268–296 (1966d).
—: Intracellularly recorded responses of the cerebellar Purkinje cells. Exp. Brain Res. 1, 161–183 (1966e).
Eccles, J.C., Sasaki, K., Strata, P.: Interpretation of the potential fields generated in the cerebellar cortex by a mossy fibre volley. Exp. Brain Res. 3, 58–80 (1967a).
—: A comparison of the inhibitory actions of Golgi cells and of basket cells. Exp. Brain Res. 3, 81–94 (1967b).
Faber, S., Murphy, J.T.: Axonal branching in the climbing fiber pathway to the cerebellum. Brain Res. 19, 262–267 (1969).
Ito, M., Hongo, T., Yoshida, M., Okada, Y., Obata, K.: Antidromic and trans-synaptic activation of Deiters neurones induced from the spinal cord. Jap. J. Physiol. 14, 638–658 (1964).
—, Kawai, N., Udo, M.: The origin of cerebellar-induced inhibition of Deiters neurones. III. Localization of the inhibitory zone. Exp. Brain Res. 4, 310–320 (1968a).
—, Mano, M.: Axon reflex activation of Deiters neurones from the cerebellar cortex through collaterals of the cerebellar afferents. Exp. Brain Res. 8, 249–268 (1969).
—, Sato, N.: Cerebellar-evoked disinhibition in dorsal Deiters neurones. Exp. Brain Res. 6, 247–264 (1968b).
—, Obata, K., Ochi, R.: The origin of cerebellar-induced inhibition of Deiters neurones. II. Temporal correlation between the transsynaptic activation of Purkinje cells and the inhibition of Deiters neurones. Exp. Brain Res. 2, 350–364 (1966).
—, Yoshida, M.: The origin of cerebellar-induced inhibition of Deiters neurones. I. Monosynaptic initiation of the inhibitory postsynaptic potentials. Exp. Brain Res. 2, 330–349 (1966).
Jansen, J., Brodal, A.: Aspects of Cerebellar Anatomy. Oslo: Johan Grundt Tanum Eorlag 1954.
Larsell, O.: The cerebellum of the cat and the monkey. J. comp. Neurol. 99, 135–200 (1953).
Oscarsson, O.: Termination and functional organization of the dorsal spino-olivocerebellar path. J. Physiol. (Lond.) 200, 129–149 (1969).
Sasaki, K., Kawaguchi, S., Shimono, T.: Interfolial mossy fibre connections in the cat cerebellum. Jap. J. Physiol. 19, 110–118 (1969).
Szentágothai, J., Rajkovits, K.: Über den Ursprung der Kletterfasern des Kleinhirns. Z. Anat. Entwickl.-Gesch. 121, 130–141 (1959).
Walberg, F., Jansen, J.: Cerebellar corticovestibular fibers in the cat. Exp. Neurol. 3, 32–52 (1961).
—: Cerebellar corticonuclear projection studied experimentally with silver impregnation method. J. Hirnforsch. 6, 338–354 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ito, M., Sato, N., Simpson, J.I. et al. Contribution of mossy fiber-granule cell pathway to the cerebellar-induced delayed inhibition in Deiters neurones. Exp Brain Res 12, 223–237 (1971). https://doi.org/10.1007/BF00237915
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00237915