Summary
Horseradish peroxidase was injected into the somata or axons of neurones located in the nucleus oralis of the spinal trigeminal complex and projecting to the accessory abducens nucleus. A group of 43 axons with electrophysiologically identified responses to the stimulation of three different areas of the face were studied. The latencies of their orthodromic responses following trigeminal stimulation and their pattern of discharges were compared to those of secondary trigeminal neurones and retractor bulbi motoneurones.
Labelled trigeminal axons were found to generate collaterals for the accessory abducens nucleus. Terminal ramifications are present in the rostro-caudal part of the motor nucleus where the dendritic arborization of the motoneurones has been described.
Connections to facial and trigeminal motor nuclei were also present, suggesting that secondary trigeminal axons distributed the information to the three motor targets at the brain stem level. It is suggested that the trigemino-retractor bulbi reflex is part of facial reflexes involved in orienting reactions, and protective responses resulting in coordinated movements of the facial musculature.
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References
Abrahams VC, Richmond FJR (1977) Motor role of the spinal projections of the trigeminal system. In: Anderson DJ, Matthews B (eds) Pain in the trigeminal region. Elsevier/ North Holland Biomedical Press, Amsterdam New York, pp 405–411
Abrahams VC, Anstee G, Richmond FJR, Rose PK (1979) Neck muscle and trigeminal input to the upper cervical cord and lower medulla of the cat. Can J Physiol Pharmacol 57: 642–651
Baker R, McCrea RA, Spencer RF (1980) Synaptic organization of cat accessory abducens nucleus. J Neurophysiol 43: 771–791
Brown AG, Rose PK, Snow PJ (1980) Dendritic trees and cutaneous receptive fields of adjacent spinocervical tract neurones in the cat. J Physiol (Lond) 300: 429–440
Brown KT, Flaming DG (1975) Instrumentation and technique for beveling fine micropipette electrodes. Brain Res 86: 172–180
Burton H, Craig AD Jr (1979) Distribution of trigeminothalamic projection cells in cat and monkey. Brain Res 161: 515–521
Burton H, Loewy AD (1977) Projections to the spinal cord from medullary somatosensory relay nuclei. J Comp Neurol 173: 773–792
Carpenter MB, Hanna GR (1961) Fiber projections from the spinal trigeminal nucleus in the cat. J Comp Neurol 117: 117–132
Chandler SH, Chase MH, Nakamura Y (1980) Intracellular analysis of synaptic mechanisms controlling trigeminal motoneuron activity during sleep and wakefulness. J Neurophysiol 44: 359–371
Christensen C, Iwata N, Kitai ST (1972) Trigemino-facial relationships in cat: A microelectrode study. Anat Rec 172: 289
Courville J (1966) The nucleus of the facial nerve; the relation between cellular groups and peripheral branches of the nerve. Brain Res 1: 338–354
Crutcher KA, Humbertson AO Jr, Martin GF (1978) The origin of brainstem-spinal pathways in the north american opossum (Didelphis virginiana). Studies using the horseradish peroxidase method. J Comp Neurol 179: 169–194
Darian-Smith I (1973) The trigeminal system. In: Iggo A (ed) Somatosensory system. Handbook of sensory physiology, vol. II. Springer, Berlin Heidelberg New York, pp 271–314
Destombes J, Durand J, Grant K, Guéritaud JP, HorcholleBossavit G, Rouvière A (1982) Electrophysiological and morphological study of identified retractor bulbi motoneurones and their trigeminal afferents in the cat. First World Congress of the IBRO on “The brain in health and disease”, Lausanne, March 31–April 6
Dubner R, Sessle BJ, Storey AT (1978) The neural basis of oral and facial function. Plenum Press, New York London
Erzurumlu RS, Killackey HP (1979) Efferent connections of the brainstem trigeminal complex with the facial nucleus of the rat. J Comp Neurol 188: 75–86
Gogan P, Guéritaud JP, Horcholle-Bossavit G, Tyc-Dumont S (1981) The vibrissal pad as a source of sensory information for the oculomotor system of the cat. Exp Brain Res 44: 409–418
Gogan P, Guéritaud JP, Tyc-Dumont S (1983) Comparison of antidromic and orthodromic action potentials recorded from identified motor axons within the brain stem of the cat. J Physiol (Lond) 335: 205–220
Graham RC, Karnovsky MJ (1966) The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney. Ultrastructural cytochemistry by a new technique. J Histochem Cytochem 14: 291–302
Grant K, Horcholle-Bossavit G (1983) Convergence of trigeminal afferents on retractor bulbi motoneurones in the anaesthetised cat. J Physiol (Lond) 339: 41–60
Grant K, Guéritaud JP, Horcholle-Bossavit G, Tyc-Dumont S (1979) Anatomical and electrophysiological identification of motoneurones supplying the cat retractor bulbi muscle. Exp Brain Res 34: 541–550
Grant K, Guegan M, Horcholle-Bossavit G (1981) The anatomical relationship of the retractor bulbi and posterior digastric motoneurones to the abducens and facial nuclei in the cat. Arch Ital Biol 119: 195–207
Guégan M, Horcholle-Bossavit G (1981) Reflex control of the retractor bulbi muscle in the cat. Pflügers Arch 389: 143–148
Guégan M, Guéritaud JP, Horcholle-Bossavit G (1978) Localisation des motoneurones du muscle retractor bulbi par transport rétrograde de peroxydase exogène chez le chat. C R Acad Sci (Paris) 286: 1355–1357
Hanker JS, Yates PE, Metz CB, Rustioni A (1977) A new specifie, sensitive and non carcinogenic reagent for the demonstration of horseradish peroxidase. Histochem J 9: 789–792
Hu JW, Dostrovsky JO, Sessle BJ (1981) Functional properties of neurons in cat trigeminal subnucleus caudalis (Medullary dorsal horn). I. Responses to oral-facial noxious and nonnoxious stimuli and projections to thalamus and subnucleus oralis. J Neurophysiol 45: 173–192
Hutson KA, Glendenning KK, Masterton RB (1979) Accessory abducens nucleus and its relationship to the accessory facial and posterior trigeminal nuclei in cat. J Comp Neurol 188: 1–16
Ikeda M (1979) Projections from the spinal and the principal sensory nuclei of the trigeminal nerve to the cerebellar cortex in the cat, as studied by retrograde transport of horseradish peroxidase. J Comp Neurol 184: 567–586
Kidokoro Y, Kubota K, Shuto S, Sumino R (1968) Reflex organization of cat masticatory muscles. J Neurophysiol 5: 695–708
Kitai ST, Tanaka T, Tsukahara N, Yu H (1972) The facial nucleus of cat: Antidromic and synaptic activation and peripheral nerve representation. Exp Brain Res 16: 161–183
Marfurt CF (1981) The central projections of trigeminal primary afferent neurons in the cat as determined by the transganglionic transport of horseradish peroxidase. J Comp Neurol 203: 785–798
Matsushita M, Okado N, Ikeda M, Hosoya Y (1980) Identification of spinal projection neurons in the trigeminal spinal and mesencephalic nuclei in the cat. A study with the retrograde horseradish peroxidase technique. In: Ito M, Tsukahara N, Kubota K, Yagi K (eds) Integrative control functions of the brain, vol 3. Kodansha-Elsevier, Tokyo Amsterdam, pp 161–163
Matsushita M, Okado N, Ikeda M, Hosoya Y (1981) Descending projections from the spinal and mesencephalic nuclei of the trigeminal nerve to the spinal cord in the cat. A study with the horseradish peroxidase technique. J Comp Neurol 196: 173–187
Matsushita M, Ikeda M, Okado N (1982) The cells of origin of the trigeminothalamic, trigeminospinal and trigeminocerebellar projections in the cat. Neuroscience 7: 1439–1454
Mesulam MM (1978) Tetramethylbenzidine for horseradish peroxidase neurochemistry: a non carcinogenic blue reactionproduct with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26: 106–107
Panneton WM, Burton H (1981) Corneal and periocular representation within the trigeminal sensory complex in the cat studied with transganglionic transport of horseradish peroxidase. J Comp Neurol 199: 327–344
Rosenblueth A, Bard P (1932) The innervation and functions of the nictitating membrane in the cat. Am J Physiol 100: 537–544
Satoh K (1979) The origin of reticulospinal fibers in the rat: A HRP study. J Hirnforsch 20: 313–332
Sherrington CS (1898) Decerebrate rigidity and reflex co-ordination of movements. J Physiol (Lond) 22: 319–332
Spencer RF, Baker R, McCrea RA (1980) Localization and morphology of cat retractor bulbi motoneurons. J Neurophysiol 43: 754–770
Sumino R, Nozaki S (1977) Trigemino-neck reflex: Its peripheral and central organization. In: Anderson DJ, Matthews B (eds) Pain in the trigeminal region. Elsevier/North Holland Biomedical Press, Amsterdam New York, pp 365–374
Székely G, Matesz C (1982) The accessory motor nuclei of the trigeminal, facial, and abducens nerves in the rat. J Comp neurol 210: 258–264
Tanaka T, Yu H, Kitai ST (1971) Trigemino and spinal inputs to the facial nucleus. Brain Res 33: 504–508
Ten Donkelaar HJ, De Boer-Van Huizen R (1978) Cells or origin of pathways descending to the spinal cord in a lizard (Lacerta galloti). Neurosci Lett 9: 123–128
Terni T (1922) Richerche sul nervo abducente e in special modo intorno al significato del suo nucleo accessorio d'origine. Folia Neurobiol 12: 277–327
Wall PD, Taub A (1962) Four aspects of trigeminal nucleus and a paradox. J Neurophysiol 25: 110–126
Yokota T, Nishikawa N (1980) Reappraisal of somatotopic tactile representation within trigeminal subnucleus caudalis. J Neurophysiol 43: 700–712
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Supported by a grant from the CNRS (ATP no. 126)
With the technical assistance of A. Rouvière, INSERM and N. Seyfritz
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Durand, J., Gogan, P., Guéritaud, J.P. et al. Morphological and electrophysiological properties of trigeminal neurones projecting to the accessory abducens nucleus of the cat. Exp Brain Res 53, 118–128 (1983). https://doi.org/10.1007/BF00239404
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DOI: https://doi.org/10.1007/BF00239404