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Reduced spinal reflexes following intrathecal baclofen in the rabbit

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Summary

Intrathecal baclofen is effective in reducing polysynaptic spinal reflexes in awake rabbits. A single lumbar infusion of 2.5–5.0 ng drug caused a significant reduction in the crossed extensor response to electrical stimulation of the plantar surface of the hindlimb. This inhibition lasted 5 h or more. At doses of 3 μ or less, the forelimbs were unaffected.

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Author notes

  1. J. S. Kroin & R. D. Penn

    Present address: Dept. of Neurosurgery, Rush Medical College, 60612, Chicago, IL, USA

  2. R. L. Beissinger

    Present address: Dept. of Chemical Engineering, Illinois Institute of Technology, 60616, Chicago, IL, USA

Authors and Affiliations

  1. Pritzker Institute of Medical Engineering, Illinois Institute of Technology, 60616, Chicago, IL, USA

    J. S. Kroin, R. D. Penn, R. L. Beissinger & R. C. Arzbaecher

Authors
  1. J. S. Kroin
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  2. R. D. Penn
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  3. R. L. Beissinger
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  4. R. C. Arzbaecher
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Kroin, J.S., Penn, R.D., Beissinger, R.L. et al. Reduced spinal reflexes following intrathecal baclofen in the rabbit. Exp Brain Res 54, 191–194 (1984). https://doi.org/10.1007/BF00235831

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  • DOI: https://doi.org/10.1007/BF00235831

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