Summary
Chronic administration of cimetidine was found to produce a fall in steady-state plasma concentrations of chlorpromazine and of indomethacin in patients. In each case there was some evidence of inhibition of metabolism, suggesting that the mechanism must therefore be decreased absorption sufficient to over-ride the metabolic change. This was confirmed by measurement of excretion of metabolites in the indomethacin study. The fall in indomethacin plasma concentrations was not associated with a change in the clinical effectiveness of the anti-inflammatory therapy.
Similar content being viewed by others
References
Brimblecenibe RW, Duncan WAM, Durant GJ, Emmett JC, Ganellin CR, Parsons ME (1975) Cimetidine — A non-thiourea H2-receptor antagonist. J Int Med Res 3: 86–92
Serlin MJ, Sibeon RG, Mossman S, Breckenridge AM, Williams JRB, Atwood JL, Willoughby JMT (1979) Cimetidine: interaction with oral anticoagulants in man. Lancet 2: 317–319
Silver BA, Bell WR (1979) Cimetidine Potentiation of the hypothrombinemic effect of warfarin. Ann Intern Med 90: 348–349
Klotz V, Reimann I (1980) Delayed clearance of diazepam due to cimetidine. N Engl J Med 302: 1012–1014
Hetzel DJ, Bochner F, Hallpike JF, Shearman DJC, Hann CS (1981) Cimetidine interaction with phenytoin. Br Med J 282: 1512
Fisher P, House F, Inns P, Morrison PJ, Rogers HJ, Bradbrook ID (1980) Effect of cimetidine on the absorption of orally administered tetracycline. Br J Clin Pharmacol 9: 153–158
Turner WJ, Turano P, March J (1970) Quantitative determination of chlorpromazine metabolites in urine. Clin Chem 16: 916
Usdin E (1971) The assay of chlorpromazine and metabolites in blood, urine and other tissues. CRC Crit R Clin Lab Sci 2: 347–391
Terweij-Groen CP, Heemstra S, Kraak JC (1980) Rapid determination of indomethacin and salicylic acid in serum by means of reversereversed-phase liquid chromatography. J Chromatogr 181: 385–397
Hajratwala BR, Dawson JE (1977) Kinetics of Indomethacin degradation. I. Presence of alkali. J Pharm Sci 66: 27–29
Ivey KJ, Mackercher PA (1978) Effect of cimetidine on ion fluxes and potential difference across the human stomach. Gut 19: 414–418
Bodemar G, Norlender B, Walan A (1977) Cimetidine in the treatment of active peptic ulcer disease. In: Burland WL, Simkins MA (eds) Cimetidine. Excerpta Medica, Amsterdam, p 224
Blackwood WS, Mandgal DP, Pickard RG, Lawrence D, Norkfield TC (1976) Cimetidine in duedenal ulcer: controlled trial. Lancet 2: 174
Haggie SJ, Fermont DC, Wyllie JH (1976) Treatment of duodenal ulcer with cimetidine. Lancet 1: 983
Bioland WL, Cleadle RI, Mills JG, Sharpe PC, Wells AL (1977) The effect of cimetidine on renal function. In: Burland WL, Simkins MA (eds) Cimetidine. Excerpta Medica, Amsterdam, pp 67–73
Hetzel DJ, Taggart CJ, Hansky J, Hecker R, Shearman DJC (1977) Cimetidine in the treatment of duodenal ulcer. Med J Aust 1: 317
Brogden RN, Heel RC, Speight TM, Avery GS (1978) Cimetidine; A review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease. Drugs 15: 93–131
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Howes, C.A., Pullar, T., Sourindhrin, I. et al. Reduced steady-state plasma concentrations of chlorpromazine and indomethacin in patients receiving cimetidine. Eur J Clin Pharmacol 24, 99–102 (1983). https://doi.org/10.1007/BF00613934
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00613934