Summary
The effect of the calcium antagonist, diltiazem, on glycoregulation was investigated in 12 healthy volunteers using a standard glucose tolerance test. No significant change was observed in plasma glucose, insulin or glucagon levels after oral treatment for B days with diltiazem 180 mg/day.
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References
Andersen L, Kolendorf K, Thorsteinsson B (1982) Nifedipine does not decrease insulin secretion. Acta Endocrinol 100 (Suppl 247) (Copenh): 7
Andersson DEH, Rojdmark S (1981) Improvement of glucose tolerance by verapamil in patients with non-insulin-dependent diabetes mellitus. Acta Med Scand 210: 27–33
Charles S, Ketelslegers JM, Buysschaert M, Lambert AE (1981) Hyperglycaemic effect of nifedipine. Br Med J 283: 19–20
Devis G, Somers G, van Obberghen E, Malaisse WJ (1975) Calcium antagonists and islet function. I. Inhibition of insulin release by verapamil. Diabetes 24: 547–551
Donnelly T, Harrower ADB (1980) Effect of nifedipine on glucose tolerance and insulin secretion in diabetic and non-diabetic patients. Curr Med Res Opin 6: 690–693
Ferlito S, Fichera C, Carra G, Puleo F, Calafato M, Volpicelli D (1981) Effect of nifedipine on blood sugar, insulin and glucagon levels after an oral glucose load. Panminerva Med 23: 75–80
Giugliano D, Torella R, Cacciapuoti F, Gentile S, Verza M, Varricchio M (1980) Impairment of insulin secretion in man by nifedipine. Eur J Clin Pharmacol 18: 395–398
Henquin JC, Lambert AE (1975) Cobalt inhibition of insulin secretion and calcium uptake by isolated rat islets. Amer J Physiol 228: 1669–1677
Herbert V, Lau KS, Gottlieb CW, Bleicher SJ (1965) Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25: 1375–1384
Leclercq-Meyer V, Marchand J, Malaisse WJ (1978) The role of calcium in glucagon release. Studies with verapamil. Diabetes 27: 996–1004
Malaisse WJ, Devis G, Herchuelz A, Sener A, Somers G (1976) Calcium antagonists and islet function. VIII. The effect of magnesium. Diab Metab 2: 1–4
Morselli PL, Rovei V, Mitchard M, Durand A, Gomeni R, Larribaud J (1979) Pharmacokinetics and metabolism of diltiazem in man. In: Bing RJ (ed). New drug therapy with a calcium antagonist. Diltiazem Hakone Symposium '78, Amsterdam. Elsevier North Holland: Amsterdam (19), pp 152–167
National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28: 1039–1057
Ostlund RE (1979) Contractile proteins and pancreatic beta cell secretion. Diabetes 26: 245–252
Rovei V, Mitchard M, Morselli PL (1977) Simple, sensitive and specific gas chromatographic method for the quantification of diltiazem in human body fluid. J Chromatogr 138: 391–398
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Segrestaa, J.M., Caulin, C., Dahan, R. et al. Effect of diltiazem on plasma glucose, insulin and glucagon during an oral glucose tolerance test in healthy volunteers. Eur J Clin Pharmacol 26, 481–483 (1984). https://doi.org/10.1007/BF00542145
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DOI: https://doi.org/10.1007/BF00542145