Summary
A combination of amoxycillin and clavulanic acid 4:1 was administered to 35 children (aged 2 to 10 years) with infections. The combination was administered orally as a suspension, every 8 h for 5 to 7 days. Sixteen children (aged 2 to 5 years), received 125 mg amoxycillin and 31.25 mg clavulanic acid, and 19 (6 to 10 years) received 250 mg amoxycillin and 62.5 mg clavulanic acid per dose. Following the first dose serum concentrations of amoxycillin and clavulanic acid were determined by microbiological assay. In the younger group receiving the lower dosage (mean: amoxycillin 9.11 mg/kg and clavulanic acid 2.34 mg/kg), the mean peak concentration of amoxycillin was 3.5 mg/l and of clavulanic acid 1.2 mg/l, occurring 1.32 h and 1.39 h, respectively, after administration. In the older group receiving the higher dosage (mean: amoxycillin 12.35 mg/kg and clavulanic acid 3.14 mg/kg) the mean peak serum level of amoxycillin was 4.0 mg/l and of clavulanic acid 1.3 mg/l, occurring 1.43 h and 1.23 h, respectively, after administration. The higher dose per kilogram body weight resulted in a higher peak serum concentration both of amoxycillin and clavulanic acid. The formulation was well tolerated by all the children and no serious side-effects were recorded. Treatment was considered clinically effective in all cases.
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Sutherland R, Croydon EAP, Rolinson G (1972) Amoxycillin: A new semi-synthetic penicillin. Br Med J 3: 13–16
Brogden RN, Speight TM, Avery GS (1975) Amoxycillin: A review of its antibacterial and pharmacokinetic properties and therapeutic use. Drugs 9: 88–140
Neu HC (ed) (1974) International symposium on amoxicillin: Clinical perspectives. J Infect Dis 129 [June Suppl]: S123–S274
Reading C, Cole M (1977) Clavulanic acid: A beta-lactamase-inhibiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother 11: 852–857
Neu HC, Fu KP (1978) Clavulanic acid, a novel inhibitor of beta-lactamases. Antimicrob Agents Chemother 14: 650–655
Wise R, Andrews JM, Bedford KA (1978) In vitro study of clavulanic acid in combination with penicillin, amoxycillin and carbenicillin. Antimicrob Agents Chemother 13: 389–393
Hunter PA, Coleman K, Fisher J, Taylor D (1980) In vitro Synergistic properties of clavulanic acid with ampicillin, amoxycillin and ticarcillin. J Antimicrob Chemother 6: 455–470
Van den Ende J, Gricius ME, De Klerk HC et al. (1982) The in vitro activity of amoxycillin with clavulanic acid against clinically significant bacteria. (A multicentre study). S Afr Med J 62 [Suppl]: 5 a-8 a
Ball AP, Farrell ID, Geddes AM, Davey P, Brookes GR (1979) Clinical and pharmacokinetic studies with clavulanic acid. Curr Chemother Infect Dis 1: 336–338
Nelson JD, Kusmeisz H, Shelton S (1982) Pharmacokinetics of potassium clavulanate in combination with amoxicillin in paediatric patients. Antimicrob Agents Chemother 21: 681–682
Ginsburg CM, McCracken GH, Thomas ML, Clahsen JC (1979) Comparative pharmacokinetics of amoxicillin and ampicillin in infants and children. Pediatrics 64: 627–631
Ball AP, Davey PG, Geddes AM, Farrell ID, Brookes GR (1980) Clavulanic acid and amoxycillin: A clinical, bacteriological and pharmacological study. Lancet 1: 620–623
Goldstein FW, Kitzis MD, Acar JF (1979) Effect of clavulanic acid and amoxycillin formulation against beta-lactamase producing Gram-negative bacteria in urinary tract infections. J Antimicrob Chemother 5: 705–709
Iravani A, Richard GA (1982) Treatment of urinary tract infections with a comination of amoxicillin and clavulanic acid. Antimicrob Agents Chemother 22: 672–677
Ball P, Watson T, Mehtar S (1981) Amoxycillin and clavulanic acid in intra-abdominal and pelvic sepsis. J Antimicrob Chemother 7: 441–444
Niname G, Joly J, Kraytman M, Piot P (1978) Bronchopulmonary infection due to beta-lactamase-producing Branhamella catarrhalis treated with amoxycillin/clavulanic acid. Lancet 2: 257
Fleisher GR, Wilmott CM, Campos JM (1983) Amoxicillin combined with clavulanic acid for the treatment of soft tissue infections in children. Antimicrob Agents Chemother 24: 679–681
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van Niekerk, C.H., van den Ende, J., Hundt, H.K.L. et al. Pharmacokinetic study of a paediatric formulation of amoxycillin and clavulanic acid in children. Eur J Clin Pharmacol 29, 235–239 (1985). https://doi.org/10.1007/BF00547429
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DOI: https://doi.org/10.1007/BF00547429