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Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone)

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Summary

The kinetics of phenobarbital (PB) was compared after oral administration of equivalent doses of the drug as the acid or the propylhexedrine salt (barbexaclone) to 7 normal volunteers. The absorption and elimination parameters were very similar. It was concluded that propylhexedrine did not affect the serum kinetics of PB given as barbexaclone.

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Authors and Affiliations

  1. Institute of Medical Pharmacology, University of Pavia, Pavia, Italy

    E. Perucca, R. Grimaldi & G. Ruberto

  2. Institute of Ophthalmology, University of Pavia, Pavia, Italy

    C. Gelmi, F. Trimarchi & A. Crema

Authors
  1. E. Perucca
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  2. R. Grimaldi
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  3. G. Ruberto
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  4. C. Gelmi
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  5. F. Trimarchi
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  6. A. Crema
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Perucca, E., Grimaldi, R., Ruberto, G. et al. Comparative kinetics of phenobarbital after administration of the acid and the propylhexedrine salt (barbexaclone). Eur J Clin Pharmacol 29, 729–730 (1986). https://doi.org/10.1007/BF00615968

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  • DOI: https://doi.org/10.1007/BF00615968

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