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2-mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria

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Summary

A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50–300 µmol/24 h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the metabolite could be a potential hazard in oxidation of fatty acids.

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Authors and Affiliations

  1. Department of Clinical Chemistry, University Hospital, Linköping, Sweden

    J. Mårtensson & B. Kågedal

  2. Department of Nephrology, University Hospital, Linköping, Sweden

    T. Denneberg

Authors
  1. J. Mårtensson
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  2. T. Denneberg
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  3. B. Kågedal
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Mårtensson, J., Denneberg, T. & Kågedal, B. 2-mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria. Eur J Clin Pharmacol 31, 119–121 (1986). https://doi.org/10.1007/BF00871000

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  • DOI: https://doi.org/10.1007/BF00871000

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