Summary
The influence of treatment with ponsinomycin, a new macrolide antibiotic, on the pharmacokinetics of cyclosporin A has been studied in 10 renal transplant patients. The pharmacokinetics of cyclosporin A was investigated at steady state, before and during treatment with ponsinomycin.
On average, the blood levels of cyclosporin A were doubled by the macrolide, possibly due to a decrease in elimination or/and to an increase in absorption.
Ponsinomycin should be use very carefully in patients treated with cyclosporin A.
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Couet, W., Istin, B., Seniuta, P. et al. Effect of ponsinomycin on cyclosporin pharmacokinetics. Eur J Clin Pharmacol 39, 165–167 (1990). https://doi.org/10.1007/BF00280052
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DOI: https://doi.org/10.1007/BF00280052