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Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals

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Summary

We determined plasma methocarbamol concentrations over 24 h following a 1.5 g methocarbamol dose (off-dialysis day) to 8 chronic haemodialysis patients and compared these results to those from 17 healthy male volunteers.

The harmonic mean elimination half-life was similar between the two groups, 1.24 and 1.14 h, respectively. tmax and the weight-adjusted Cmax were 1.1 h and 27.0 mg · m−1 for haemodialysis patients and 1.1 and 23.1 mg · l−1 for normals. Relative systemic availability was assessed by comparing weight-normalized AUC × k10 products.

These results indicate no significant differences with respect to methocarbamol absorption, with the relative systemic availability in patients being 113%.

These data suggest that absorption and elimination of methocarbamol is similar between normal subjects and patients undergoing maintenance haemodialysis.

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Authors and Affiliations

  1. Renal Pharmacology Section, Division of Nephrology, Richmond, Virginia

    D. A. Sica & J. Davis

  2. Department of Pharmacy and Pharmaceutics, Medical College of Virginia, Richmond, Virginia

    T. J. Comstock

  3. Department of Drug Metabolism, A. H. Robins Co., Richmond, Virginia

    L. Manning, R. Powell, A. Melikian & G. Wright

Authors
  1. D. A. Sica
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  2. T. J. Comstock
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  3. J. Davis
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  4. L. Manning
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  5. R. Powell
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  6. A. Melikian
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  7. G. Wright
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Sica, D.A., Comstock, T.J., Davis, J. et al. Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol 39, 193–194 (1990). https://doi.org/10.1007/BF00280060

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  • DOI: https://doi.org/10.1007/BF00280060

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