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The effect of food on the interaction of ofloxacin with sucralfate in healthy volunteers

  • Pharmacokinetics and Disposition
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Abstract

We have studied the effect of food on the interaction of ofloxacin with sucralfate. Six healthy men took a single oral dose of ofloxacin (200 mg) on 4 occasions: alone after overnight fasting or after breakfast (non-fasting), and with sucralfate fasting or non-fasting.

There were no significant differences in the plasma concentration-time profiles of ofloxacin after ofloxacin alone between fasting and non-fasting conditions. On the other hand, the peak plasma concentration and AUC of ofloxacin after co-administration with sucralfate while fasting fell by 70 and 61 % compared with ofloxacin alone; the changes non-fasting were 39 and 31 % respectively. The interaction of ofloxacin with sucralfate was markedly reduced by food, but still could not be disregarded.

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Authors and Affiliations

  1. Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, 113, Tokyo, Japan

    J. Kawakami, H. Kotaki, T. Seino, Y. Sawada & T. Iga

  2. Department of Geriatrics, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, 113, Tokyo, Japan

    T. Matsuse, Y. Fukuchi & H. Orimo

Authors
  1. J. Kawakami
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  2. H. Kotaki
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  3. T. Seino
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  4. Y. Sawada
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  5. T. Iga
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  6. T. Matsuse
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  7. Y. Fukuchi
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  8. H. Orimo
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Kawakami, J., Kotaki, H., Seino, T. et al. The effect of food on the interaction of ofloxacin with sucralfate in healthy volunteers. Eur J Clin Pharmacol 47, 67–69 (1994). https://doi.org/10.1007/BF00193481

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  • DOI: https://doi.org/10.1007/BF00193481

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