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Comparative pharmacokinetics of sodium- and methylglucamine diatrizoate in urography

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Summary

Comparative tests were carried out, using a radioactive tracer method, on the pharmacokinetics of sodium and methylglucamine diatrizoate. A biological model was simulated using an analogue computer; and the rate and elimination constants, the elimination half life, and the ratio of tissue entry to tissue elimination constants were calculated. Over the period of time required for X-ray diagnosis, the two salts of the contrast medium acid which were tested did not alter the pharmacokinetics of the contrast medium itself.

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Authors and Affiliations

  1. Klinik für Radiologie, Nuklearmedizin und Physikalische Therapie, Medizinische Klinik und Poliklinik des Klinikum Steglitz der Freien Universität Berlin and Department Biodynamik der Schering AG, Berlin, Germany

    V. Taenzer, P. Koeppe, K. F. Samwer & G. H. Kolb

Authors
  1. V. Taenzer
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  2. P. Koeppe
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  3. K. F. Samwer
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  4. G. H. Kolb
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Taenzer, V., Koeppe, P., Samwer, K.F. et al. Comparative pharmacokinetics of sodium- and methylglucamine diatrizoate in urography. Eur J Clin Pharmacol 6, 137–140 (1973). https://doi.org/10.1007/BF00562441

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  • DOI: https://doi.org/10.1007/BF00562441

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