Summary
The effect of renal failure on the excretion of oral doses of practolol has been studied. The plasma half-life increased up to 6.6 times normal and the cumulative urinary excretion of the drug was reduced. There was a linear correlation between the overall elimination rate constant of practolol and inulin and creatinine clearances. A linear correlation was also found between the renal clearances of practolol and inulin. The dose of practolol required for maintenance therapy should be reduced in patients with impaired renal function.
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The results have been presented in part as a thesis for the M.D. degree of the University of Giessen.
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Bodem, G., Grieser, H., Eichelbaum, M. et al. Pharmacokinetics of practolol in renal failure. Eur J Clin Pharmacol 7, 249–252 (1974). https://doi.org/10.1007/BF00560339
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DOI: https://doi.org/10.1007/BF00560339