Summary
Characteristic computed tomographic, clinical and pathologic features are discussed in two patients with cerebral amyloid angiopathy (CAA) associated with massive intracerebral hemorrhage. Amyloid angiopathy should be considered in any elderly patient in whom intracerebral hemorrhage occurs at an atypical site. Cortical involvement, multiplicity of hemorrhages, bilaterality, and repeated episodes should further arouse diagnostic suspicion. Clinical management is confined to prevention of systemic hypertension.
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References
Vanley CT, Aguilar MJ, Kleinhenz RJ, Lagios MD (1981) Cerebral amyloid angiopathy. Hum Pathol 12: 609–616
Okoye MI, Watanabe I (1982) Ultrastructural features of cerebral amyloid angiopathy. Hum Pathol 13: 1127–1132
Lee SS, Stemmermann GN (1978) Congophilic angiopathy and cerebral hemorrhage. Arch Pathol Lab Med 102: 317–321
Okazaki H, Reagan TJ, Campbell RJ (1979) Clinicopathologic studies of primary cerebral anyloid angiopathy. Mayo Clin Proc 54: 22–31
Mandybur TL, Bates SRD (1978) Fatal massive intracerebral hemorrhage complicating cerebral amyloid angiopathy. Arch Neurol 35: 246–248
Tyler KL, Poletti CE, Heros RC (1982) Cerebral amyloid angiopathy with multiple intracerebral hemorrhages. Case report. J Neurosurg 57: 286–289
Nagle WA, Smith TW, Weiner M (1984) Intracerebral hemorrhage caused by cerebral amyloid angiopathy: radiographic-pathologic correlation. AJNR 5: 171–176
Patel DV, Hier DB, Thomas CM, Hemmati M (1984) Intracerebral hemorrhage secondary to cerebral amyloid angiopathy. Radiology 151: 397–400
Glenner GG (1980) Amyloid deposits and amyloidosis. The B-fibrilloses. N Engl J Med 302: 1333–1343
Wright JR, Calkins E, Breen WJ, Stolte G, Schultz RT (1969) Relationship of amyloid to aging. Review of the literature and systematic study of 83 patients derived from a general hospital population. Medicine 48: 39–60
Vinters HV, Gilbert JJ (1981) Amyloid angiopathy: its incidence and complications in the aging brain. Abstract. Stroke 12: 118
Wright JR, Calkins E (1974) Relationship of amyloid deposits in the human aorta to aortic atherosclerosis: a postmortem study of 100 individuals over 60 years of age. Lab Invest 30: 767–773
Griffiths RA, Mortimer TF, Oppenheimer DR, Spalding JMK (1982) Congophilic angiopathy of the brain: a clinical and pathological report on two siblings. J Neurol Neurosurg Psychiatry 45: 396–408
Mandybur TL, Gore I (1969) Amyloid in late postirradiation necrosis of brain. Neurology 19: 983–992
Bruni J, Bilbao JM, Pritzker KPH (1977) Vascular amyloid in the aging central nervous system. Clinico-pathological study and literature review. Can J Neurol Sci 4: 239–244
Heffuer RR, Porro RS, Olson ME, Earle KM (1976) A demyelinating disorder associated with cerebrovascular amyloid angiopathy. Arch Neurol 33: 501–506
Peterson EW, Schulz DM (1961) Amyloid in vessels of a vascular malformation in brain. Arch Pathol 72: 480–483
Cole FM, Yates PO (1967) The occurence and significance of intracerebral micro-aneurysms. J Pathol 93: 393–411
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Sobel, D.F., Baker, E., Anderson, B. et al. Cerebral amyloid angiopathy associated with massive intracerebral hemorrhage. Neuroradiology 27, 318–321 (1985). https://doi.org/10.1007/BF00339564
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DOI: https://doi.org/10.1007/BF00339564