Abstract
Mineralizing microangiopathy, a distinctive histopathologic process involving the microvasculature of the central nervous system (CNS), is usually seen following combined radiation and chemotherapy for the treatment of CNS neoplasms in childhood. CT typically demonstrates calcification within the basal ganglia and subcortical white matter. The areas of calcification may give paradoxically increased signal on T1-weighted MRI due to a surface-relaxation mechanism, and decreased signal on T2-weighted images.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Priee RA, Birdwell DA (1978) The central nervous system in childhood leukemia. Cancer 42: 717–728
Peylan-Ramu N, Poplack DG, Pizzo PA, et al (1978) Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy. N Engl J Med 298: 815–818
Flament-Durand J, Ketelbant-Balasse P, Maurus R, et al (1975) Intracerebral calcifications appearing during the course of acute lymphocytic leukemia treated with methotrexate and x rays. Cancer 35: 319–325
Henkelman RM, Watts JF, Kucharczyk W (1991) High signal intensity in MR images of calcified brain tissue. Radiology 179: 199–206
Valk PE, Dillon WP (1991) Radiation injury of the brain. AJNR 156: 689–706
Kramer S, Lee KF (1974) Complications of radiation therapy: the central nervous system. Semin Roentgenol 9: 75–83
Ebner F, Ranner G, Slavc I, et al (1989) MR findings in methotrexate induced CNS abnormalities. AJR 153: 1283–1288
Ball WS, Prenger EC, Ballard ET (1992) Neurotoxicity of radio/chemotherapy in children: pathologic and MR correlation. AJNR 13: 761–766
Kim EE, Chung S, Haynie TP, et al (1992) Differentiation of residual or recurrent tumors from posttreatment changes with F-18 FDG PET. Radiographics 12: 269–279
Segebarth CM, Baleriaux DF, Arnold DL, et al (1987) MR image-guided P-31 MR spectroscopy in the evaluation of brain tumor treatment. Radiology 165: 215–219
Ogawa T, Kanno I, Shishido F, et al (1991) Clnical value of PET with18F-fluorodeoxyglucose and L-methyl-11C-methionine for diagnosis of recurrent brain tumor and radiation injury. Acta Radiol 32: 197–202
Kramer JH, Norman D, Brant-Zawadzki M, et al (1988) Absence of white matter changes on magnetic resonance imaging in children treated with CNS prophylaxis therapy for leukemia. Cancer 61: 928–930
Aoki S, Okada Y, Nishimura K, et al (1989) Normal deposition of brain iron in childhood and adolescence: MR imaging at 1.5 T. Radiology 172: 381–385
Drayer BP (1988) Imaging of the aging brain. Radiology 166: 785–796
Cohen CR, Duchesneau PM, Weinstein MA (1980) Calcification of the basal ganglia as visualized by computed tomography. Radiology 134: 97–99
Ho VB, Fitz CR, Chuang SH, et al (1993) Bilateral basal ganglia lesions: pediatric differential considerations. Radiographics 13: 269–292
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shanley, D.J. Mineralizing microangiopathy: CT and MRI. Neuroradiology 37, 331–333 (1995). https://doi.org/10.1007/BF00588350
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00588350