Summary
We examined the effect of dimethylsulfoxide (DMSO) on the absorption of a chemotherapeutic drug instilled into the bladder. Female Wistar rats with bladder tumors underwent intravesical instillation of normal saline (S group) or 50% DMSO (D group) prior to the administration of pirarubicin (tetrahydropyranyl-Adriamycin). The absorption of pirarubicin was estimated histologically by observing its fluorescence. In the S group, fluorescence of pirarubicin was observed only in the epithelial layer of normal or hyperplastic regions and in the cells of superficial layers of the tumor. In the D group fluorescence was observed in the entire bladder wall of normal or hyperplastic regions and extended to deeper regions of the tumors than in the S group. These findings indicate enhancement of the absorption of pirarubicin by pretreatment with DMSO.
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Hashimoto, H., tokunaka, S., Sasaki, M. et al. Dimethylsulfoxide enhances the absorption of chemotherapeutic drug instilled into the bladder. Urol. Res. 20, 233–236 (1992). https://doi.org/10.1007/BF00299723
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DOI: https://doi.org/10.1007/BF00299723