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Renal handling of urate and oxalate: Possible implications for urolithiasis

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Summary

Both urate and oxalate are organic acids of considerable clinical interest, owing to their limited solubility. Calcium oxalate is the most frequent constituent of renal calculi and occasionally precipitates in body fluids. Urate precipitations are common in the kidney and in various other tissues. In this paper, a short outline of the present knowledge of renal handling of these substances will be followed by some conclusions as to the possible relevance of this knowledge for the understanding of urolithiasis and intrarenal precipitation. Direct (micropuncture) data are available for urate in the rat (1,6, 7, 10, 21, 23, 28, 36, 42), rabbit (35), dog (34) and cebus monkey (33) and in the rat only for oxalate (11, 15, 20).

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References

  1. Abramson, R. G., Levitt, M. F.: Micropuncture study of uric acid transport in rat kidney. American Journal of Physiology 228, 1597 (1975)

    Google Scholar 

  2. Catall, W. R., Spencer, A. G., Tailor, G. W., Watts, R. W. E.: The mechanism of the renal excretion of oxalate in the dog. Clinical Science 22, 43 (1962)

    Google Scholar 

  3. Danowitch, C. M., Weinberger, J., Berlyne, G. M.: Uric acid in advanced renal failure. Clinical Science 43, 331 (1972)

    Google Scholar 

  4. Davis, B. B., Field, J. B., Rodnan, G. P., Kedes, L. H.: Localization and pyrazinamide inhibition of distal transtubular movement of uric acid-2C14 with a modified stop-flow-technique. Journal of Clinical Investigation 44, 716 (1965)

    Google Scholar 

  5. Fischer, V., Heidland, A., Kluetsch, K., Gekle, D.: Phosphat- und Harnsäuretransport bei terminaler Niereninsuffizienz. Verhandlungen der deutschen Gesellschaft für innere Medizin 74, 1064 (1968)

    Google Scholar 

  6. Greger, R., Lang, F., Deetjen, P.: Handling of uric acid by the rat kidney. I. Microanalysis of uric acid in proximal tubular fluid. Pflügers Archiv 324, 279 (1971)

    Google Scholar 

  7. Greger, R., Lang, F., Deetjen, P.: Urate handling by the rat kidney. IV. Reabsorption in the loops of Henle. Pflügers Archiv 352, 115 (1974)

    Google Scholar 

  8. Greger, R., Lang, F., Puls, F., Deetjen, P.: Urate interaction with plasma proteins and erythrocytes. Possible mechanism for urate reabsorption in kidney medulla. Pflügers Archiv 352, 121 (1974)

    Google Scholar 

  9. Greger, R., Lang, F., Deetjen, P.: Renal excretion of purine metabolites, urate and allantoin, by the mammalian kidney. In: Intern. Rev. Physiol., Kidney and Urinary Tranct Physiology II, Vol. 11, Thurau, K., (ed.). Baltimore: Univesity Park Press 1976

    Google Scholar 

  10. Greger, R., Lang, F., Deetjen, P., Knox, F. G.: Sites of urate transport in the rat nephron. In: Purine Metabolism in Man II. Müller, M. M., Kaiser, E., Seegmiller, J. E. New York: Plenum Press 1977

    Google Scholar 

  11. Greger, R., Lang, F., Oberleithner, H., Deetjen, P.: Handling of oxalate by the rat kidney. Pflügers Archiv 374, 243 (1978)

    Google Scholar 

  12. Griebsch, A., Zöllner, N.: Renal uric acid excretion evaluated over periods of one day and one month using balance techniques in normal and hyperuricemic subjects. International Symposium on amino acid and uric acid transport. Silbernagl, S., Lang, F., Greger, R., (eds.). Stuttgart, New York: Thieme 1975

    Google Scholar 

  13. Gutman, A. B., Yu, T. F., Sirota, J. H.: Contrasting effects of bicarbonate and diamox with equivalent alkalization of urine on salicylate uricosuria in man. Federation Proceeding 15, 85 (1956)

    Google Scholar 

  14. Häberle, D.: Influence of glomerular filtration rate on the rate of p-aminohippurate secretion by the rat kidney: micropuncture and clearance studies. Kidney International 7, 385 (1975)

    Google Scholar 

  15. Hautmann, R., Osswald, H.: Die renale Ausscheidung des Oxalats Clearance- und erste Mikropunktionsuntersuchungen. In: Pathogenese und Klinik der Harnsteine V. Gasser, G., Vahlensieck, W., (eds.) Darmstadt: Dietrich Steinkopff Verlag 1977

    Google Scholar 

  16. Hodgkinson, A., Wilkinson, R.: Plasma oxalate concentration and renal excretion of oxalate in man. Clinical Science and Molecular Medicine 46, 61 (1974)

    Google Scholar 

  17. Hodgkinson, A., Wilkinson, R., Nordin, B. E. C.: The concentration of oxalic acid in human blood. In: Urinary Calculi. Delatte, L. C., Rapado, A., Hodgkinson, A., (eds.). pp. 18–23. Basel: S. Karger 1973

    Google Scholar 

  18. Hodgkinson, A.: Oxalate metabolism and Hyperoxaluria. In: Scientific Foundations in Urology. Williams, D. I., Chisholm, G. D., (eds.). Vol. 1. London: William Heineman Medical Books, 1976

    Google Scholar 

  19. Kessler, R. H., Hierholzer, K., Curd, R. S.: Localization of urate transport in the nephron of mongrel and dalmatian dog kidney. American Journal of Physiology 197, 601 (1959)

    Google Scholar 

  20. Knight, T. F., Senekjian, H. O., Weinman, E. J.: The Effect of paraaminohyppurate on the renal transport of oxalate. Kidney International in press (1979)

  21. Kramp, R. A., Lassiter, W. E., Gottschalk, C. W.: Urate-2-14C transport in the rat nephron. Journal of Clinical Investigation 50, 35 (1971)

    Google Scholar 

  22. Kramp, R. A., Lenoir, R.: Distal permeability to urate and effects of benzofuran derivates in the rat kidney. American Journal of Physiology 228, 875 (1975)

    Google Scholar 

  23. Lang, F., Greger, R., Deetjen, P.: Handling of uric acid by the rat kidney. II. Microperfusion studies on bidirectional transport of uric acid in the proximal tubule. Pflügers Archiv 335, 257 (1972)

    Google Scholar 

  24. Lang, F., Greger, R., Deetjen, P.: Effect of Diuretics on Uric Acid Metabolism and Excretion. In: Diuretics in Research and Clinics. Siegenthaler, W., Beckerhoff, R., Vetter, W., Stuttgart: Georg Thieme 1977

    Google Scholar 

  25. Lang, F., Greger, R., Deetjen, P.: Factors affecting urate reabsorption in the rat kidney. In: Purine Metabolism in Man II. ed.: Müller, M. M., Kaiser, E., Seegmiller, J. E.: New York: Plenum Press 1977

    Google Scholar 

  26. Lang, F., Greger, R., Oberleithner, H., Deetjen, P.: Studies on renal handling of urante in man. VIIth International Congress on Nephrology Montreal 1978

  27. Machtey, I., Meer, A.: Certain physiological stress conditions in the problem of hyperuricaemia. International Symposium on Purine Metabolism in Man. Tel Aviv, 1973

  28. Oelert, H., Baumann, K., Gekle, D.: Permeabilitätsmessungen einiger schwacher organischer Säuren aus dem distalen Konvolut der Rattenniere. Pflügers Archiv 307, 178 (1969)

    Google Scholar 

  29. Ogryzlo, M. A.: Hyperuricemia induced by high fat diets and starvation. Arthritis and Rheumatism 8, 799 (1965)

    Google Scholar 

  30. Padova, J., Bendersky, G.: Hyperuricaemia in diabetic Ketoacidosis. New England Journal Medicine 267, 530 (1962)

    Google Scholar 

  31. Podevin, R., Ardaillou, R., Paillard, F., Fontanelle, J., Richet, G.: Etude chez l'homme de la cinetique d'apparition dans l'urine de l'acide urique 2-14-C. Nephron 5, 134 (1968)

    Google Scholar 

  32. Rieselbach, R. E., Steele, T. H.: Influence of kidney upon urate homeostasis in health and disease. American Journal of Medicine 56, 665 (1974)

    Google Scholar 

  33. Roch-Ramel, F., Weiner, I. M.: Excretion of urate by the kidneys of cebus monkeys: a micropuncture study. American Journal of Medicine 224, 1369 (1973)

    Google Scholar 

  34. Roch-Ramel, F., Wong, N. L. M., Dirks, J. H.: Renal excretion of urate in mongrel and Dalmatian dogs: a micropuncture study. American Journal of Physiology 231, 326 (1976)

    Google Scholar 

  35. Roch-Ramel, F., De Rougemont, D., Peters, G., Weiner, I. M.: Micropuncture study of urate excretion by the kidney of the rat, the cebus monkey and the rabbit. In Amino Acid Transport and Uric Acid Transport. Silbernagl, S., Lang, F., Greger, R., (eds.). Stuttgart: Thieme Verlag 1976

    Google Scholar 

  36. Roch-Ramel, F., Diezi-Chomety, F., De Rougemont, D., Tellier, M., Widmer, J., Peters, G.: Renal excretion of uric acid in the rat: a micropuncture and microperfusion study. American Journal of Physiology 230, 768 (1976)

    Google Scholar 

  37. Scott, J. T., McCallum, F. M., Holloway, V. P.: Starvation, ketosis and uric acid excretion. Clinical Science 27, 209 (1964)

    Google Scholar 

  38. Sonnenberg, H., Oelert, H., Baumann, K.: Proximal tubular reabsorption of some organic acids in the rat kidney in vivo. Pflügers Archiv 286, 171 (1965)

    Google Scholar 

  39. Srensen, L. B.: The elimination of uric acid in man studied by means of C14 labelled uric acid: uricolysis. Scandinavian Journal of Clinical and Laboratory Investigation (Supplement) 54, 1 (1960)

    Google Scholar 

  40. Steele, T. H., Oppenheimer, S.: Factors affecting urate excretion following diuretic administration in man. American Journal of Medicine 47, 564 (1969)

    Google Scholar 

  41. Suki, W. N., Hull, A. R., Rector, F. C., Seldin, D. W.: Mechanism of the effect of thiazide diuretics on calcium and uric acid. Journal of Clinical Investigation 46, 1121 (1967)

    Google Scholar 

  42. Weinmann, J. E., Steplock, D., Suki, W. N., Eknoyan, G.: Urate reabsorption in proximal vonvoluted tubule of the rat kidney. American Journal of Physiology 231, 509 (1976)

    Google Scholar 

  43. Weinmann, E. J., Frankfurt, S. J., Ince, A., Sansom, S.: Renal tubular transport of organic acids. Studies with oxalate and para-aminohippurate in the rat. Journal of Clinical Investigation 61, 801 (1978)

    Google Scholar 

  44. Williams, H. E., Johnson, G. A., Smitz jr, L. H.: The renal clearance of oxalate in normal subjects and patients with primary hyperoxaluria. Clinical Science 41, 213 (1971)

    Google Scholar 

  45. Yü, T. F., Berger, L., Kupfer, S., Gutman, A. B.: Tubular secretion of urate in the dog. American Journal of Physiology 199, 1199 (1960)

    Google Scholar 

  46. Zins, G. R., Weiner, I. M.: Bidirectional urate transport limited to the proximale tubule in dogs. American Journal Physiology 215, 411 (1968)

    Google Scholar 

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Authors and Affiliations

  1. Institute of Physiology and Balneology, University of Innsbruck, Innsbruck, Austria

    F. Lang, R. Greger, H. Sporer, H. Oberleithner & P. Deetjen

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  1. F. Lang
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  2. R. Greger
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  3. H. Sporer
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  4. H. Oberleithner
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  5. P. Deetjen
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Lang, F., Greger, R., Sporer, H. et al. Renal handling of urate and oxalate: Possible implications for urolithiasis. Urol. Res. 7, 143–148 (1979). https://doi.org/10.1007/BF00257198

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