Abstract
In most individuals two HLA-DR β genes are expressed from each chromosome. One of these genes encodes one of the classical DR specificities, while the other encodes either of the supertypic DRw52/DRw53 specificities. In addition to these genes usually one or two DR β pseudogenes are present. In contrast, the DRw8 chromosomal region only contains a single DR β gene. To determine the relationship of this single gene to the multiple DR β genes of other DR specificities, comparisons of Southern genomic blots were carried out. In this analysis genomic clones for each individual DR β chain locus were included. The DR β w8 gene was indistinguishable from the DR β III gene of DR3 cells (encoding DRw52), suggesting that it is closely related to the latter gene. The functional implications of this finding are discussed.
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Andersson, G., Lindblom, B., Andersson, L. et al. The single DR β gene of the DRw8 haplotype is closely related to the DR β 3III gene encoding DRw52. Immunogenetics 28, 1–5 (1988). https://doi.org/10.1007/BF00372522
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DOI: https://doi.org/10.1007/BF00372522