Skip to main content
Log in

Physical mapping of theRing1, Ring2, Ke6, Ke4, Rxrb, Col11a2, andRT1.Hb genes in the rat major histocompatibility complex

  • Original Paper
  • Published:
Immunogenetics Aims and scope Submit manuscript

Abstract

A contig of cosmids containing theRing1, Ring2, Ke6, Ke4, Rxrb, andCol11a2 genes in the rat major histocompatibility complex has been established and aligned to the class II cluster (RT1.Hb). The relative order and the transcriptional orientations of these rat genes are the same as in their human and mouse homologues. The distances are also similar, except for theCol11a2—class II interval, which is clearly shorter in rat and mouse compared with human. The previously definedKe5 probe could be shown to map into the largeCol11a2 gene.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Abe, K., Wei, J.-F., Wei, F.-S., Hsu, Y.-C., Uehara, H., Artzt, K., and Bennett, D. Searching for coding sequences in the mammalian genome: theH-2K region of the mouse MHC is replete with genes expressed in embryos.EMBO J 7: 3441–3449, 1988

    PubMed  CAS  Google Scholar 

  • Arimura, Y., Tang, W. R., Koda, T., and Kakinuma, M. Structure of novel rat major histocompatibility complex class II genesRT1.Ha andHb.Immunogenetics 41: 320–325, 1995a

    Article  PubMed  CAS  Google Scholar 

  • Arimura, Y., Tang, W. R., Koda, T., and Kakinuma, M. Cloning and analysis of a new rat major histocompatibility complex class II gene,RT1. DOa.Immunogenetics 42: 156–158, 1995b

    Article  PubMed  CAS  Google Scholar 

  • Aziz, N., Maxwell, M. M., St.-Jacques, B., and Brenner, B. M. Down-regulation ofKe6, a novel gene encoded within the major histocompatibility complex, in murine polycystic kidney disease.Mol Cell Biol 13: 1847–1853, 1993

    PubMed  CAS  Google Scholar 

  • Diamond, A. G., Hood, L. E., Howard, J. C., windle, M., and Winoto, A. The class II genes of the rat MHC.J Immunol 142: 3268–3274, 1989

    PubMed  CAS  Google Scholar 

  • Hamada, K., Gleason, S. L., Levi, B.-Z., Hirschfeld, S., Apella, E., and Ozato, K. H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of the major histocompatibility class I genes and the estrogen response element.Proc Natl Acad Sci USA 86: 8289–8293, 1989

    Article  PubMed  CAS  Google Scholar 

  • Hanson, I. M., Gorman, P., Lui, V. C. H., Cheah, K. S. E., Solomon, E., and Trowsdale, J. The human a2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6.Genomics 5: 925–931, 1989

    Article  PubMed  CAS  Google Scholar 

  • Hanson, I. M. and Trowsdale, J. Colinearity of novel genes in the class II regions of the MHC in mouse and human.Immunogenetics 34: 5–11, 1991

    Article  PubMed  CAS  Google Scholar 

  • Hanson, I. M., Poustka, A., and Trowsdale, J. New genes in the class II region of the human major histocompatibility complex.Genomics 10: 417–424, 1991

    Article  PubMed  CAS  Google Scholar 

  • Hughes, A. L. Independent gene duplications, not concerted evolution, explain relationships among class I MHC genes of murine rodents.Immunogenetics 33: 367–373, 1991

    Article  PubMed  CAS  Google Scholar 

  • Jameson, S. C., Tope, W. D., Tedgett, E. M., Windle, J. M., Diamond, A.G., and Howard, J. C. Cloning and expression of class I major histocompatibility complex genes of the rat.J Exp Med 175: 1749–1757, 1992

    Article  PubMed  CAS  Google Scholar 

  • Kimura, T., Cheah, K. S. E., Chan, S. D., Lui, V. C. H., Mattei, M.-G., Van der Rest, M., Ono, K., Solomon, E., Ninomiya, Y., and Olson, B. R. The human a2(XI) collagen (COL11A2) chain: molecular cloning of cDNA and genomic DNA reveal characteristics of a fibrillar collagen with differences in genomic organization.J Biol Chem 264: 13910–13916, 1989

    PubMed  CAS  Google Scholar 

  • Kirisits, M. J., Sawai, H., Kunz, H. W., and Gill, T. J. III. MultipleTL-like loci in thegrc-G/C region of the rat.Immunogenetics 39: 301–315, 1994

    PubMed  CAS  Google Scholar 

  • Larsson, M., Tissir, F., Walter, L., Günther, E., Jacob, H., Klinga-Levan, K., and Levan, G. Mapping of the rat ribosomal protein S18 gene (Rps18) to chromosome 20p12.Mammalian Genome 7: 90, 1996

    Article  PubMed  CAS  Google Scholar 

  • Lovering, R., Hanson, I. M., Borden, K. L. B., Martin, S., O'Reilly, N. J., Evan, G. I., Rahman, D., Papping, D. J. C., Trowsdale, J., Freemont, P. S. Identification and preliminary characterization of a protein motif related to the zinc finger.Proc Natl Acad Sci USA 90: 2112–2116, 1993

    Article  PubMed  CAS  Google Scholar 

  • Nagata, T., Weiss, E. H., Abe, K., Kitagawa, K., Ando, A., Yara-Kikuti, Y., Seldin, M. F., Ozato, K., Inoko, H., and Taketo, M. Physical mapping of the retinoic X receptorB gene in mouse and human.Immunogenetics 41: 83–90, 1995

    Article  PubMed  CAS  Google Scholar 

  • St.-Jacques, B., Han, T.-H., MacMurray, A., and Shin, H.-S. A putative transmembrane protein with histidine-rich charge clusters encoded in theH-2K/t w5 region of mice.Mol Cell Biol 10: 138–145, 1990

    PubMed  CAS  Google Scholar 

  • Stubbs, L., Lui, V. C. H., Ng, L. J., and Cheah, K. S. E. The α2(XI) collagen gene lies within 8 kb ofPb in the proximal portion of the murine major histocompatibility complex.Mamm Genome 4: 95–103, 1993

    Article  PubMed  CAS  Google Scholar 

  • Tsumaki, N. and Kimura, T. Differential expression of an acidic domain in the amino-terminal propeptide of mouse pro-alpha 2(XI) collagen by complex alternative splicing.J Biol Chem 270: 2372–2378, 1995

    Article  PubMed  CAS  Google Scholar 

  • Vuristo, M. M., Pihlajamaa, T., Vandenberg, P., Prockop, D. J., and Ala-Kokko, L. The humanCOL11A2 gene structure indicates that the gene has not evolved with the gene for the major fibrillar collagens.J Biol Chem 270: 22873–22881, 1995

    Article  PubMed  CAS  Google Scholar 

  • Walter, L., Rauh, F., and Günther, E. Comparative analysis of the three major histocompatibility complex-linkedHsp70 genes of the rat.Immunogenetics 40: 325–330, 1994

    Article  PubMed  CAS  Google Scholar 

  • Walter, L. and Günther, E. Cosmid cloning of the RT1. A encompassing region of the rat major histocompatibility complex.Transplant Proc 27: 1501, 1995

    PubMed  CAS  Google Scholar 

  • Walter, L., Tiemann, C., Heine, L., and Günther, E. Genomic organization and sequence of the rat major histocompatibility complex class Ia geneRT1.A u.Immunogenetics 41: 332, 1995

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

The nucleotide sequence data reported in this paper have been submitted to the EMBL/GenBank nucleotide sequence database and have been assigned the accession numbers X95474, X95868, X95869, X95870, X95871, X95872, and X95873

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walter, L., Fischer, K. & Günther, E. Physical mapping of theRing1, Ring2, Ke6, Ke4, Rxrb, Col11a2, andRT1.Hb genes in the rat major histocompatibility complex. Immunogenetics 44, 218–221 (1996). https://doi.org/10.1007/BF02602588

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02602588

Keywords

Navigation