Summary
The aim of this paper is to apply a computer control scheme to a laboratory scale fermentor so that the specific growth rate in a baker's yeast fed-batch culture, which cannot be measured directly, will follow as accurately as possible the desired profile specified in advance. Using an extended Kalman filter and programmed controller/feedback compensator (PF) system proposed previously, profile control of the specific growth rate (μ) was achieved experimentally in a baker's yeast fed-batch culture. Also, bang-bang type profile control of μ minimized the proportion of budding cells, which have a strong correlation with the fermentative activity in bread-making.
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Shimizu, H., Shioya, S., Suga, Ki. et al. Profile control of the specific growth rate in fed-batch experiments. Appl Microbiol Biotechnol 30, 276–282 (1989). https://doi.org/10.1007/BF00256218
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DOI: https://doi.org/10.1007/BF00256218