Abstract
Biotransformation of 1-benzoylindole (BI) by the strains Aspergillus flavus VKM F-1024 and Aspergillus oryzae VKM F-44 was studied. The major metabolites isolated were identified as 4-hydroxyindole (4-HI), 5-hydroxyindole (5-HI), 4-hydroxy-1-benzoylindole, 4-hydroxy-1-(4′-hydroxy)-benzoylindole and indole. The structure of the metabolites was determined by mass spectrometry and proton nuclear magnetic resonance spectroscopy. The pathways of BI metabolism via initial monohydroxylation at C-4 and C-5 followed by cleavage of the benzoyl substituent to yield 4-HI and 5-HI were proposed. Indole was formed as a by-product, and its role as a potent inhibitor of BI hydroxylation at C-4 and C-5 is discussed.
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Received: 22 June 1999 / Received revision: 6 December 1999 / Accepted: 12 December 1999
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Sukhodolskaya, G., Nikolayeva, V., Donova, M. et al. Conversion of 1-benzoylindole by Aspergillus strains. Appl Microbiol Biotechnol 53, 695–700 (2000). https://doi.org/10.1007/s002530000317
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DOI: https://doi.org/10.1007/s002530000317