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Spermidine level as a parameter in the treatment of patients with malignant melanoma

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Abstract

Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay. Baseline values were normal in 17 courses, a doubling of plasma levels following chemotherapy occurred in 13 courses. There was no relation between the occurrence of a tumor response and an increase in spermidine levels nor between hematological toxicity or digestive tract toxicity and spermidine levels.

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Authors and Affiliations

  1. Department of Medical Oncology, University Hospital, Groningen, The Netherlands

    J. M. Smit, H. Jurjens, J. Bouman, J. Bijzet, D. Th. Sleijfer & N. H. Mulder

  2. Department of Nuclear Medicine, University Hospital, Groningen, The Netherlands

    J. M. Smit, H. Jurjens, J. Bouman, J. Bijzet, D. Th. Sleijfer & N. H. Mulder

Authors
  1. J. M. Smit
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  2. H. Jurjens
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  3. J. Bouman
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  4. J. Bijzet
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  5. D. Th. Sleijfer
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  6. M. G. Woldring
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  7. N. H. Mulder
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Smit, J.M., Jurjens, H., Bouman, J. et al. Spermidine level as a parameter in the treatment of patients with malignant melanoma. Eur J Nucl Med 10, 276–277 (1985). https://doi.org/10.1007/BF00254474

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  • DOI: https://doi.org/10.1007/BF00254474

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