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Technegas and Pertechnegas particle size distribution

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Abstract

Technegas and Pertechnegas are radioactive aerosols produced in a commercial generator and used for lung scintigraphy. The aerosols are produced by first evaporating to dryness standard technetium-99m generator eluate (99m-TcO4 in normal saline) in a graphite crucible (thesimmer stage) and then heating this to 2500° C (the „burn” stage). The aim of this work was to measure the particle size distributions of these agents and relate this to regional lung deposition. Factors that may vary during production of the aerosol in routine use were investigated to determine whether they influenced the particle size. Activity size distributions were measured using a serial wire-screen diffusion battery. The Technegas size distribution was approximately log-normal with an activity median diameter of 158 nm and a geometric standard deviation of 1.5. The results for Pertechnegas were similar. The median size increased with the number of simmers and with the time from generation. The increase in size with the number of simmers is thought to be due to the increased salt content in the crucible prior to the „burn”. The predicted lung deposition is 37% in the alveolar region and 5% in the bronchial region. Significant changes in deposition are not predicted over the range of particle sizes measured.

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References

  1. Isawa T, Teshima Y, Anazawa Y, Miki M, Motomiya M. Technegas for inhalation lung imaging.Nucl Med Commun 1991; 12: 47–55.

    PubMed  Google Scholar 

  2. James JM, Herman KJ, Lloyd JJ, Shields RA, Testa HJ, Church S, Stretton TB. Evaluation of 99m-Tc Technegas ventilation scintigraphy in the diagnosis of pulmonary embolism.Br J Radiol 1991; 64: 711–719.

    PubMed  Google Scholar 

  3. Burch WM, Sullivan PJ, McLaren CJ. Technegas — a new ventilation agent for lung scanning.Nucl Med Commun 1986; 7: 865–871.

    PubMed  Google Scholar 

  4. Monaghan P, Provan I, Murray C, Mackey DWJ, Van der Wall H, Walker BM, Jones PD. An improved radionuclide technique for the detection of altered pulmonary permeability.J Nucl Med 991; 32: 1945–1949.

  5. Burch WM, Boyd MM, Crellin DE. Technegas: particle size and distribution [letter].Eur J Nucl Med 1994; 21: 356–366.

    Google Scholar 

  6. Strong JC, Agnew JE. The particle size distribution of Technegas and its influence on regional lung deposition.Nucl Med Commun 1989; 10: 425–430.

    PubMed  Google Scholar 

  7. Lemb M, Oei TH, Eifert H, Gunther B. Technegas: a study of particle structure, size and distribution.Eur J Nucl Med 1993; 20:576–579.

    PubMed  Google Scholar 

  8. Sinclair D, Hoopes GS. A novel form of diffusion battery.Am Ind Hyg Assoc J 1975; 36: 39–42.

    PubMed  Google Scholar 

  9. Cheng YS, Keating JA, Kanapilly GM. Theory and calibration of screen-type diffusion battery.J Aerosol Sci 1980; 11: 549–556.

    Google Scholar 

  10. Twomey S. Comparison of constrained linear inversion and an iterative nonlinear algorithm applied to the indirect estimation of particle size distributions.J Comput Phys 1975; 18: 188–200.

    Google Scholar 

  11. Bellen JC, Penglis S, Tsopelas C. Radiochemical characterization of modified technegas.Nucl Med Biol 1993; 20: 715–717.

    PubMed  Google Scholar 

  12. Lloyd JJ, Taylor CS, Shields RA. Analysis of diffusion battery data using simulated annealing. Aerosols; their generation behaviour and applications. Proceedings of the eighth annual conference of the aerosol society. University of York; 1994: 29–34.

  13. Cheng Y-S, Yeh H-C. Analysis of screen diffusion battery data.Am Ind Hyg Assoc J 1984; 45: 556–561.

    Google Scholar 

  14. Stahlhofen W, Rudolf G, James AC. Intercomparison of experimental regional aerosol deposition data.J Aerosol Med 1989; 2: 285–308.

    Google Scholar 

  15. Lloyd JJ, James JM, Shields RA, Testa HJ. The influence of inhalation technique on Technegas particle deposition and image appearance in normal volunteers.Eur J Nucl Med 1994; 21:394–398.

    PubMed  Google Scholar 

  16. Mackey DWJ, Burch WM, Dance IG, Fisher KJ, Willett GD. The observation of fullerenes in a Technegas lung ventilation unit.Nucl Med Commun 1994; 15: 430–434.

    PubMed  Google Scholar 

  17. Baggott J. Great balls of carbon.New Scientist 6 July 1991: 34–38.

  18. Weast RC, Astle MJ, Beyer WH.CRC handbook of chemistry and physics. Boca Raton: CRC Press, 1988.

    Google Scholar 

  19. Zebel G. Coagulation of aerosols. In: Davies CN, ed.Aerosol science. London: Academic Press; 1966:31–58.

    Google Scholar 

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Authors and Affiliations

  1. Department of Medical Physics, Manchester Royal Infirmary, Oxford Rd., M13 9WL, Manchester, UK

    J. J. Lloyd, R. A. Shields & R. S. Lawson

  2. Department of Medical Biophysics, Manchester University, Manchester, UK

    C. J. Taylor

  3. Department of Nuclear Medicine, Manchester Royal Infirmary, Manchester, UK

    J. M. James & H. J. Testra

Authors
  1. J. J. Lloyd
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  2. R. A. Shields
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  3. C. J. Taylor
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  4. R. S. Lawson
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  5. J. M. James
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  6. H. J. Testra
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Lloyd, J.J., Shields, R.A., Taylor, C.J. et al. Technegas and Pertechnegas particle size distribution. Eur J Nucl Med 22, 473–476 (1995). https://doi.org/10.1007/BF00839062

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  • DOI: https://doi.org/10.1007/BF00839062

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