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Canine osteosarcoma failure of intravenous or intralesional BCG as adjuvant immunotherapy

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Summary

Dogs with spontaneous osteosarcoma of an extremity were entered into two consecutive trials of adjuvant immunotherapy with BCG. In the first trial, 30 dogs underwent amputation followed by intravenous BCG, 0.4−1.6×108 viable organisms, on the day of amputation, 1 and 3 weeks later and then monthly for 1 year. In the second trial, 2−8×108 viable BCG organisms or 6 mg BCG cell walls in oil were injected intralesionally 10–26 (median=17) days before amputation. Neither time to development of metastatic disease nor survival was prolonged by either immunotherapy protocol.

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References

  1. Au FC, Webber B, Rosenberg SA (1978) Pulmonary granulomas induced by BCG. Cancer 41:2209

    Google Scholar 

  2. Baldwin RW, Pimm MV (1973) BCG immunotherapy of pulmonary growths from intravenously transferred rat tumour cells. Br J Cancer 27:48

    Google Scholar 

  3. Baldwin RW, Pimm MV (1978) BCG in tumor immunotherapy. Adv Cancer Res 28:91

    Google Scholar 

  4. Bartlett GL, Zbar B, Rapp HJ (1972) Suppression of murine tumor growth by immune reaction to the Bacillus Calmette-Guérin strain of Mycobacterium bovis. J Natl Cancer Inst 48:245

    Google Scholar 

  5. Brodey RS, Abt DA (1976) Results of surgical treatment in 65 dogs with osteosarcoma. J Am Vet Med Assoc 168:1032

    Google Scholar 

  6. Cohen D (1978) The transmissible venereal tumor of the dog — a naturally occurring allograft? Isr J Med Sci 14:14

    Google Scholar 

  7. Cotter SM, Parker LM (1978) High-dose methotrexate and leucovorin rescue in dogs with osteogenic sarcoma. Am J Vet Res 39:1943

    Google Scholar 

  8. Eilber FR, Townsend CM, Morton DL (1978) Adjuvant immunotherapy of osteosarcoma with BCG and allogeneic tumor cells. In: Immunotherapy of cancer: Present status of trials in man. Raven Press, New York, p 299

    Google Scholar 

  9. Henness AM, Theilen GH, Park RD, Buhles WC (1977) Combination therapy for canine osteosarcoma. J Am Vet Med Assoc 170:1076

    Google Scholar 

  10. Hess AD, Catchatourian R, Zander AR, Epstein RB (1977) Intralesional Bacillus Calmette-Guérin immunotherapy of canine venereal tumors. Cancer Res 37:3990

    Google Scholar 

  11. Kleinschuster SJ, Rapp HJ, Lueker DC, Kainer RA (1977) Regression of bovine ocular carcinoma by treatment with a mycobacterial vaccine. J Natl Cancer Inst 58:1807

    Google Scholar 

  12. Mathé G, Olsson L (1979) Systemic active immunotherapy is shifting from the middle ages to a renaissance period. II. Experimental models for cancer systemic immunotherapy and immunoprophylaxis. Cancer Immunol Immunother 6:197

    Google Scholar 

  13. Misdorp W (1980) Animal model: Canine osteosarcoma. Am J Pathol 98:285

    Google Scholar 

  14. Moore M, Lawrence N, Witherow PJ (1974) Suppression of transplanted rat sarcomata mediated by Bacillus Calmette-Guérin (BCG). Eur J Cancer 10:673

    Google Scholar 

  15. Morton DL, Eilber FR, Holmes EC, Sparks FC, Ramming KP (1976) Present status of BCG immunotherapy of malignant melanoma. Cancer Immunol Immunother 1:93

    Google Scholar 

  16. Nathanson L (1972) Regression of intradermal malignant melanoma after intralesional injection of Mycobacterium bovis strain BCG. Cancer Chemother Rep 56:659

    Google Scholar 

  17. Owen LN, Bostock DE, Levelle RB (1977) Studies of therapy of osteosarcoma in dogs using BCG vaccine. J Am Vet Radiol Soc 18:27

    Google Scholar 

  18. Pinsky C, Hirshaut I, Oettgen H (1972) Treatment of malignant melanoma by intratumoral injection of BCG. Proc Am Assoc Cancer Res (Abstract)

  19. Rapp HJ (1977) Of cavies and men: The propriety and rationality of “cancer immunotherapy”. (Guest editorial) J Natl Cancer Inst 59:1577

    Google Scholar 

  20. Rosenberg SA, Chabner BA, Young RC, Seipp CA, Levine AS, Costa J, Hanson TA, Head GC, Simon RM (1979) Treatment of osteogenic sarcoma. I. Effect of adjuvant high-dose methotrexate after amputation. Cancer Treat Rep 63:739

    Google Scholar 

  21. Spradbrow PB, Wilson BE, Hoffmann D, Kelly WR, Francis J (1977) Immunotherapy of bovine ocular squamous cell carcinomas. Vet Res 100:376

    Google Scholar 

  22. Theilen GH, Leighton R, Pool R, Park RD (1977) Treatment of canine osteosarcoma for limb preservation using osteotomy, adjuvant radiotherapy and chemotherapy (a case report). Vet Med Small Anim Clin 72:179

    Google Scholar 

  23. Weiden PL, Storb R, Kolb HJ, Ochs HD, Graham TC, Tsoi MS, Schroeder ML, Thomas ED (1974) Immune reactivity in dogs with spontaneous malignancy. J Natl Cancer Inst 53:1049

    CAS  PubMed  Google Scholar 

  24. Weiden PL, Storb R, Tsoi MS, Deeg HJ, Graham TC (1978) Canine osteosarcoma: Results of amputation with and without adjuvant immunotherapy. Cancer Immunol Immunother 5:181

    Google Scholar 

  25. Zbar B, Tanaka T (1971) Immunotherapy of cancer: Regression of tumors after intralesional injection of living Mycobacterium bovis. Science 172:271

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center and the Department of Medicine, Division of Oncology, University of Washington School of Medicine, 1124 Columbia Street, 98104, Seattle, WA, USA

    P. L. Weiden, H. J. Deeg, T. C. Graham & R. Storb

Authors
  1. P. L. Weiden
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  2. H. J. Deeg
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  3. T. C. Graham
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  4. R. Storb
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Dr. Deeg is a Fellow of the Leukemia Society of America

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Weiden, P.L., Deeg, H.J., Graham, T.C. et al. Canine osteosarcoma failure of intravenous or intralesional BCG as adjuvant immunotherapy. Cancer Immunol Immunother 11, 69–72 (1981). https://doi.org/10.1007/BF00205777

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  • DOI: https://doi.org/10.1007/BF00205777

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