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Amphotericin B plus combination chemotherapy for extensive non-small cell bronchogenic carcinoma

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  • Amphotericin B and Chemotherapy in Lung Cancer
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Summary

Sixteen patients with extensive non-small carcinoma of the lung were treated with methotrexate, vincristine, cyclophosphamide, and adriamycin. Cyclophosphamide and adriamycin were administered after pretreatment with amphotericin B. Amphotericin B-related toxicity was mild; cytotoxic chemotherapy-related toxicity was tolerable. The partial response rate was 12.5% and median survival was between 19 and 20 weeks. Response rate and survival were not superior to those of a similar drug combination lacking amphotericin B.

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Authors and Affiliations

  1. Department of Medicine, UCLA Center for Health Sciences, 90024, Los Angeles

    Gregory Sarna & Martin J. Cline

  2. Division of Hematology/Oncology, UCLA Center for Health Sciences, 90024, Los Angeles

    Gregory Sarna & Martin J. Cline

  3. Department of Medicine, Veterans Administration Hospital, Sepulveda, CA, USA

    Barry B. Lowitz & Patricia A. Ganz

  4. Division of Hematology/Oncology, Veterans Administration Hospital, Sepulveda, CA, USA

    Barry B. Lowitz & Patricia A. Ganz

Authors
  1. Gregory Sarna
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  2. Barry B. Lowitz
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  3. Patricia A. Ganz
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  4. Martin J. Cline
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Sarna, G., Lowitz, B.B., Ganz, P.A. et al. Amphotericin B plus combination chemotherapy for extensive non-small cell bronchogenic carcinoma. Cancer Chemother. Pharmacol. 5, 89–92 (1980). https://doi.org/10.1007/BF00435410

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  • DOI: https://doi.org/10.1007/BF00435410

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