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Absence of antitumor activity of ORG 5895, a 11β-aziridinylmethyl derivative of estradiol, on the MXT mammary tumor and the P388 leukemia

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  • ORG 5895
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References

  1. Connors TA (1975) Mechanism of action of 2-chloro-ethylamine derivatives, sulfur mustards, epoxides and aziridines. Sartorelli AG, Johns DG (eds) In: Antineoplastic and immunosuppressive agents. II. Springer, Berlin, p 18

    Google Scholar 

  2. Devleeschouwer N, Gangji D, Leclercq G, Heuson JC (1980) In vitro and in vivo assessment of hormone dependence in the MXT murine mammary tumor. Cancer Chemother Pharmacol [Suppl] 5: 14

    Google Scholar 

  3. Geran RI, Greenberg NH, MacDonald MM, Schumacher AM, Abbott BJ (1972) Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother Rep 3: 1

    Google Scholar 

  4. Leclercq G, Devleeschouwer N, Legros N, Heuson JC (1980) In vitro screening for cytotoxic estrogens of potential therapeutic activity. In: Raus J, Martens H, Leclercq G (eds) Cytotoxic estrogens in hormone receptive tumors. Academic Press, London, p 165

    Google Scholar 

  5. Schönemann KH, Van Vliet NP, Zeelen FJ (1980) Potential antitumor agents: 11β-(1-aziridinylmethyl) derivatives of oestradiol and oestrone. Eur J Med Chem 15: 333

    Google Scholar 

  6. Watson C, Medina D, Clark JH (1979) Characterization and estrogen stimulation of cytoplasmic progesterone receptor in the ovarian-dependent MXT-3590 mammary tumor line. Cancer Res 39: 4098

    Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Cancérologie mammaire, Service de Médicine, Institut Jules Bordet, Rue Héget-Bordet 1, B-1000, Brussels, Belgium

    N. Devleeschouwer & G. Leclercq

  2. Laboratoire d'Histologie, Faculté de Médicine, Université Libre de Bruxelles, B-1000, Brussels, Belgium

    A. Danguy

  3. Laboratoire de Chimiothérapie expérimentale et Screening, Service de Médecine, Institut Jules Bordet, B-1000, Bruxelles, Belgium

    G. Atassi

Authors
  1. N. Devleeschouwer
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  2. G. Leclercq
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  3. A. Danguy
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  4. G. Atassi
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Devleeschouwer, N., Leclercq, G., Danguy, A. et al. Absence of antitumor activity of ORG 5895, a 11β-aziridinylmethyl derivative of estradiol, on the MXT mammary tumor and the P388 leukemia. Cancer Chemother. Pharmacol. 8, 315–316 (1982). https://doi.org/10.1007/BF00254057

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  • DOI: https://doi.org/10.1007/BF00254057

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