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In vitro drug release from chitosan membranes

Study of the mechanisms of permeation

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Summary

In vitro studies of controlled release from chitosan membranes were carried out using drugs of different molecular weight. The release rate was measured in water at 37°±0.5°C by determining the amount of drug released by spectrophotometric analysis. It was found that release of acetamide, nicotinamide, sodium benzoate, sodium salicylate, phenobarbital sodium and sodium cefazoline followed zero-order kinetics. The relation between molecular weight and diffusion coefficient was established.

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Authors and Affiliations

  1. Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Suc. 16, C.C. 61, 5016, Córdoba, Argentina

    M. M. Bonvin & M. M. de Bertorello

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  1. M. M. Bonvin
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  2. M. M. de Bertorello
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Bonvin, M.M., de Bertorello, M.M. In vitro drug release from chitosan membranes. Polymer Bulletin 32, 69–75 (1994). https://doi.org/10.1007/BF00297416

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  • DOI: https://doi.org/10.1007/BF00297416

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