Summary
The clinical efficacy and adverse effects of nandrolone decanoate (Deca-Durabolin) were investigated in a double-blind placebo-controlled multicentre study in female patients with systemic lupus erythematosus (SLE). The patients received 100 mg Deca-Durabolin or placebo once every 2 weeks for 3 months. At the end of the study, 36 patients (18 on placebo and 18 on Deca-Durabolin) were evaluated. Beneficial effects were observed on arthralgia, and/or arthritis and minor vasculitis. Possible beneficial effects were seen on polymyalgia, active SLE rash, oral and/or nasal ulcerations and pleural and pericardial pain in the Deca-Durabolin-treated patients. The overall clinical assessment score showed that Deca-Durabolin would influence the disease course by lowering significantly the disease activity score. However, this treatment is still hampered by adverse reactions such as voice alterations and hirsutism. Therefore, the development of androgen-derived steroids free from androgenic activity should be encouraged, since these compounds may contribute to a new therapeutic modality in female SLE patients.
Similar content being viewed by others
References
Maddock RK Jr (1965) Incidence of systemic lupus erythematosus by age and sex. JAMA 191:173–183
Jungers P, Dougados M, Pelissier C, Kuttenn F, Thon F, Lesavre P, Bach JF (1982) Lupus nephropathy and pregnancy: report of 104 cases in 36 patients. Arch Intern Med 142:771–776
Jungers P, Dougados M, Pelissier C, Kuttenn F, Thon F, Lesavre P, Bach JF (1982) Influence of oral contraceptive therapy on the activity of systemic lupus erythematosus. Arthritis Rheum 25:618–623
Stern R, Fishman J, Busman H, Kunkel HG (1970) Systemic lupus erythematosus associated with Klinefelter's syndrome. Arthritis Rheum 20:18–22
French MAH, Hughes P (1988) Systemic lupus erythematosus and Klinefelter's syndrome. Ann Rheum Dis 42:471–473
Lahita RG, Bradlow HL, Kunkel HG, Fishman J (1981) Increased 16 alpha-hydroxylation of estradiol in systemic lupus erythematosus. J Clin Endocrinol Metab 53:174–178
Lahita RG, Kunkel HG, Bradlow HL (1983) Increased oxidation of testosterone in systemic lupus erythematosus Arthritis Rheum 26:1517–1521
Jungers P, Nahoul K, Pelissier C, Dougados M, Tron F, Bach JF (1982) Low plasma androgens in women with active or quiescent systemic lupus erythematosus. Arthritis Rheum 25:454–457
Lahita RG, Bradlow HL, Ginzler F, Pang S, New M (1987) Low plasma androgens in women with systemic lupus erythematosus. Arthritis Rheum 30:241–248
Miller MH, Krowitz MB, Gladman DD, Killinger DW (1983) Systemic lupus erythematosus in males. Medicine 62:327–334
Roubinian JR, Talal N, Greenspan JS, Goodman JR, Siiteii K (1978) Effect of castration and sex hormone treatment on survival, antinucleic acid antibodies, and glomerulonephritis in NZB/NZW F mice. J Exp Med 147:1568–1583
Talal N (1976) Disordered immunologic regulation and autoimmunity. Transplant Rev 31:240–248
Fanandez GE, Yunis J, Good RA (1974) Age and genetic influence on immunity in NZB and auto-immune resistant mice. Clin Immunol Immunopathol 6:318
Roubinian JR, Papoian R, Talal N (1977) Androgenic hormones modulate auto-antibody responses and improve survival in murine lupus. J Clin Invest 59:1066–1070
Melez RA, Boegen WA, Steinberg AD (1980) Therapeutic studies in New Zeeland mice VII. Successful androgen treatment of NZB/NZW F, females of different ages. Arthritis Rheum 23:41–47
Verheul HAM (1981) The effects of nandrolone, testosterone and their decanoate esters on murine lupus. Clin Exp Immunol 44:11–17
Hazelton RA, Mc Cruden AB, Sturrock RD, Stimson WH (1983) Hormonal manipulation of the immune response in systemic lupus erythematosus: a drug trial of an anabolic steroid, 19-nor testosterone. Ann Rheum Dis 42:155–157
Jungers P, Kuttenn, Liote F, Pelissier C, Athea N, Laurent M, Viriot J, Dougados M, Bach JF (1985) Hormonal modulation in systemic lupus erythematosus: preliminary clinical and hormonal results with cyproterone acetate. Arthritis Rheum 28:1243–1250
Agnello V, Pariser K, Gell J, Gelfand J, Turksoy RN (1983) Preliminary observation on danazol therapy of systemic lupus erythematosus: effects on DNA antibodies, thrombocytopenia and complement. J Rheumatol 10:682–687
Tan EM, Cohen AS, Fries JF (1982) The 1982 revised criteria for the classification of SLE. Arthritis Rheum 25:1271–1277
Swaak AJG, Groenwold J, Aarden LA, Statius van Eps LW, Feltkamp TWE (1982) Prognostic value of anti-ds DNA in systemic lupus erythematosus. Ann Rheum Dis 41:388
Swaak AJG, Aarden LA, Statius van Eps LW, Feltkamp TEW (1979) Anti-ds DNA and complement profiles as prognostic guides in systemic lupus erythematosus. Arthritis Rheum 22:226–235
Dubois EL (1974) Lupus erythematosus, 2nd edn. University of Southern California Press, Los Angeles, p 242
Stahl NI, Decker JL (1978) Androgenic status of males with systemic lupus erythematosus. Arthritis Rheum 21:665–668
Lahita RG, Bardlow HL, Kunkel HG, Fishman J (1979) Alterations of estrogen metabolism in systemic lupus erythematosus. Arthritis Rheum 22:1195–1198
Ahmed SA, Dauphinee MJ, Talal N (1985) Effects of short term administration of sex hormones on normal and auto-immune mice. Immunol 134:204–210
Paaronent LC, Andersson H, Adlercreutz H (1981) Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen stimulated cultures. J Exp Med 154:1935–1945
Cutolo M, Balleari E, Giuisti M, Intra E, Accardo S (1991) Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum 34:1–5
Drosos AA, van Vliet-Daskalopoulou E, Andonopoulos AP, Galanopoulou V, Skopouli FN, Moutsopoulos HM (1988) Nandrolone decanoate (Deca-Durabolin) in primary Sjögren's syndrome: a double-blind pilot study. Clin Exp Rheumatol 6:53–57
Swaak AJG, Nossent JC, Bronsveld W, van Rooyen A, Nieuwenhuys EJ, Theuns L, Smeenk RJT (1989) Systemic lupus erythematosus. I. Outcome and survival: Dutch experience with 110 patients studied prospectively. Ann Rheum Dis 48:447–454
Swaak AJG, Nossent JC, Bronsveld W, Nieuwenhuys EJ, Theuns L, Smeenk RJT (1989) Systemic lupus erythematosus. II. Observations on the occurrence of exacerbations in the disease course: Dutch experience with 110 patiens studied prospectively. Ann Rheum Dis 48:455–460
Overbeek GA, Visser de J (1961) A comparison of the myotrophic and androgenic activities of the phenylpropionates and decanoates of testosterone and anadrolone. Acta Endocrinol 38:285–292
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Swaak, A.J.G., van Vliet Daskalopoulou, E., Cutolo, M. et al. Effect of nandrolone decanoate (Deca-Durabolin) on the disease activity of female patients with systemic lupus erythematosus. Rheumatol Int 13, 237–240 (1994). https://doi.org/10.1007/BF00290201
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00290201