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Rheumatoid nodules without rheumatoid arthritis

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Summary

Four female patients with rheumatoid nodules are described who had no other clinical manifestations of rheumatoid disease. Only one of the patients was seropositive for the rheumatoid factor and HLA-DR4. Nosologic aspects of such isolated rheumatoid nodules are discussed.

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References

  1. Gordon DA, Stein JL, Broder I (1973) The extra-articular features of rheumatoid arthritis. A systematic analysis of 127 cases. Am J Med 54:445–452

    Google Scholar 

  2. Moore CP, Willkens RF (1977) The subcutaneous nodule: its significance in the diagnosis of rheumatic disease. Semin Arthritis Rheum 7:63–79

    Google Scholar 

  3. Hahn BH, Yardley JH, Stevens MB (1970) “Rheumatoid” nodules in systemic lupus erythematosus. Ann Intern Med 72:49–58

    Google Scholar 

  4. Dubois EL, Friou GJ, Chandor S (1972) Rheumatoid nodules and rheumatoid granulomas in systemic lupus erythematosus. JAMA 220:515–518

    Google Scholar 

  5. Ruderman JE, Abruzzo JL (1966) Chronic postrheumatic fever arthritis (Jaccoud's): report of a case with subcutaneous nodules. Arthritis Rheum 9:640–647

    Google Scholar 

  6. London MG, Bland JH (1963) Ankylosing spondylitis with subcutaneous nodules. N Engl J Med 268:991–994

    Google Scholar 

  7. Smythe HA (1956) Marie-Strümpell spondylitis with rheumatoid nodules (Abstract). Ann Rheum Dis 15:271

    Google Scholar 

  8. Barnett EV, Winkelstein A, Weinberger HJ (1970) Agammaglobulinemia with polyarthritis and subcutaneous nodules. Am J Med 48:40–47

    Google Scholar 

  9. Beatty EC (1959) Rheumatic-like nodules occurring in non-rheumatic children. Arch Pathol 68:154–159

    Google Scholar 

  10. Draheim JH, Johnson LC, Helwig EB (1959) A clinicopathologic analysis of “rheumatoid” nodules occurring in 54 children (Abstract). Am J Pathol 35:678

    Google Scholar 

  11. Altman RS, Caffrey PR (1964) Isolated subcutaneous rheumatic nodules. Pediatrics 34:869–872

    Google Scholar 

  12. Mesara BW, Brody GL, Oberman HA (1966) “Pseudorheumatoid” subcutaneous nodules. Am J Clin Pathol 45:684–691

    Google Scholar 

  13. Burrington JD (1970) “Pseudorheumatoid” nodules in children: report of 10 cases. Pediatrics 45:473–478

    Google Scholar 

  14. Berardinelli JL, Hyman CJ, Chambell EE, Fireman P (1972) Presence of rheumatoid factor in ten children with isolated rheumatoid-like nodules. J Pediatr 81:751–757

    Google Scholar 

  15. Simons FER, Schaller JG (1975) Benign rheumatoid nodules. Pediatrics 56:29–33

    Google Scholar 

  16. Belin DC, Abeles M, Weinstein A (1979) Rheumatoid markers in the absence of arthritis. J Rheumatol 6:293–299

    Google Scholar 

  17. Brown MM, Hadler NM, Sams WM, Wilson J, Snyderman R (1979) Rheumatoid nodulosis. Sporadic and familial diseases. J Rheumatol 6:286–292

    Google Scholar 

  18. Stastny P (1982) The HLA-D region and the genetics of rheumatoid arthritis. In: Ziff M, Velo GP, Gorini S (eds) Advances in inflammation research, vol 3, Rheumatoid arthritis. Raven Press, New York, pp 41–48

    Google Scholar 

  19. Terasaki PJ, Mc Clelland JD (1964): Microdroplet assay of human serum cytotoxins. Nature 204:998–1000

    Google Scholar 

  20. Rood JJ van, Leeuwen A van, Keuning JJ, Bussé van Oud Alblas A (1975) The serological recognition of the human MLC determinants using a modified cytotoxicity technique. Tissue Antigens 5:73–79

    Google Scholar 

  21. Sokoloff L, McCluskey RT, Bunim JJ (1953) Vascularity of the early subcutaneous nodule of rheumatoid arthritis. Arch Pathol 55:475–495

    Google Scholar 

  22. Bywaters EGL (1949) A variant of rheumatoid arthritis characterized by recurrent digital pad nodules and palmar fasciitis, closely resembling palindromic rheumatism. Ann Rheum Dis 8:2–30

    Google Scholar 

  23. Watt TL, Baumann RR (1967) Pseudoxanthomatous rheumatoid nodules. Arch Dermatol 95:156–160

    Google Scholar 

  24. Ginsberg MH, Genant HK, T'Sai Fan Yü, Mc Carty DJ (1975) Rheumatoid nodulosis. An unusual variant of rheumatoid disease. Arthritis Rheum 18:49–58

    Google Scholar 

  25. Brower AC, Na Pombejara C, Stechschulte DJ, Mantz F, Ketchum L (1977) Rheumatoid nodulosis: another cause of juxta-articular nodules. Radiology 125:669–670

    Google Scholar 

  26. Wisnieski JJ, Askari AD (1981) Rheumatoid nodulosis. A relatively benign rheumatoid variant. Arch Intern Med 141: 615–619

    Google Scholar 

  27. Fowler JK (1884) Subcutaneous nodules in an adult not the subject of rheumatism. Br Med J 1:107

    Google Scholar 

  28. Kosmin M, Vail JT, Sturmann MJ, Luke DR (1964) Streptococcal infection and isolated rheumatic-like subcutaneous nodules. A case report. Med Bull US Army (Europe) 21: 28–29

    Google Scholar 

  29. Akers WA, Miller DA (1966) Rheumatoid nodules in adult without rheumatoid arthritis. Arch Dermatol 93:428–431

    Google Scholar 

  30. Sturgill BC, Allan JH (1970) Rheumatoid-like nodules presenting as “pump bumps” in a patient without rheumatoid arthritis. Arthritis Rheum 13:175–179

    Google Scholar 

  31. Feagler JR, Sorenson GD, Rosenfeld MG, Osterland CK (1971) Rheumatoid pleural effusion. Arch Pathol 92:257–266

    Google Scholar 

  32. Askari A, Moskowitz RW, Goldberg VM (1974) Subcutaneous rheumatoid nodules and serum rheumatoid factor without arthritis. JAMA 229:319–320

    Google Scholar 

  33. Ganda OP, Caplan HI (1974) Rheumatoid disease without joint involvement. JAMA 228:338–339

    Google Scholar 

  34. Frayha R, Ayyash R, Gehshan A, Gemayel N (1976) Rheumatoid disease without arthritis. Johns Hopkins Med J 139:69–72

    Google Scholar 

  35. Burke GW, Carrington CB, Grinnan R (1977) Pulmonary nodules and rheumatoid factor in the absence of arthritis. Chest 72:538–540

    Google Scholar 

  36. Lowney ED, Simons HM (1963) “Rheumatoid” nodules of the skin. Their significance as an isolated finding. Arch Dermatol 88:853–858

    Google Scholar 

  37. Nerup J, Cathelineau C, Seignalet J, Thomsen M (1977) HLA and endocrine diseases. In: Dausset J, Svejgaart A (eds) HLA and disease, 1st edn. Munksgaard, Copenhagen, pp 149–167

    Google Scholar 

  38. Wood MG, Beerman H (1960) Necrobiosis lipoidica, granuloma anulare, and rheumatoid nodule. J Invest Dermatol 34:139–147

    Google Scholar 

  39. Elliott GB, Hill RH, Kliman MR, Elliott JDA (1973) Deep granuloma anulare and “non-rheumatoid nodule”. Cutis 11:76–80

    Google Scholar 

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Authors and Affiliations

  1. Medizinische Poliklinik der Universität München, Pettenkoferstrasse 8 a, D-8000, München, Federal Republic of Germany

    P. Herzer, H. S. Füeßl & M. Schattenkirchner

  2. Labor für Immungenetik, Kinderpoliklinik der Universität München, D-8000, München, Federal Republic of Germany

    S. Scholz

Authors
  1. P. Herzer
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  2. S. Scholz
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  3. H. S. Füeßl
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  4. M. Schattenkirchner
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Herzer, P., Scholz, S., Füeßl, H.S. et al. Rheumatoid nodules without rheumatoid arthritis. Rheumatol Int 2, 183–187 (1982). https://doi.org/10.1007/BF00286142

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  • DOI: https://doi.org/10.1007/BF00286142

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