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Effects of60Co radiation on the cellular responses in degenerating dorsal columns in the rat spinal cord

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Summary

Rats were irradiated with doses of 1 000–3 000 rads to the cervical spinal cord and subsequently given a paralytic dose of p-Bromophenylacetylurea. The nuclear populations in the degenerating dorsal columns were determined and it was found that a significant suppression of cell proliferation occurred after all three dose levels. The cell populations in the shielded parts of the tracts rostral to the irradiated zone were not affected.

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Author notes

  1. J. W. Hopewell

    Present address: Department of Radiobiology, Churchill Hospital, Oxford, England

Authors and Affiliations

  1. The M. R. C. Research Group in Applied Neurobiology, Institute of Neurology, Queen Square, London

    J. B. Cavanagh, J. W. Hopewell & F. C. K. Chen

  2. The Department of Biology, St. Mary's Hospital Medical School, London

    J. B. Cavanagh, J. W. Hopewell & F. C. K. Chen

Authors
  1. J. B. Cavanagh
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  2. J. W. Hopewell
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  3. F. C. K. Chen
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Cavanagh, J.B., Hopewell, J.W. & Chen, F.C.K. Effects of60Co radiation on the cellular responses in degenerating dorsal columns in the rat spinal cord. Acta Neuropathol 19, 318–322 (1971). https://doi.org/10.1007/BF00692152

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  • DOI: https://doi.org/10.1007/BF00692152

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