Summary
An electron microscope study and quantitation of myelinated and unmyelinated fibers of seven nerve biopsies performed in sporadic cases of idiopathic sensory neuropathy is reported. The number of myelinated fibers is markedly decreased or absent in every case. On the contrary, the unmyelinated fiber numbers are normal or increased. In most cases, the small diameter myelinated and unmyelinated fibers proportions are higher than those of control biopsies. The electron microscope study discloses evidence of degeneration of Wallerian type and regeneration is also indicated by quantitative studies. Regenerative phenomena seem more obvious in sporadic cases than in previously reported studies of familial cases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Bibliographie
Appenzeller, O., Kornfeld, M., Snyder, R.: Acromulating, paralysing neuropathy with corneal ulceration in Navajo children. Arch. Neurol.33, 733–738 (1976)
Bureau, Y., Barriere, H., Kerneis, J.-P., Ferron, A.: Acropathies ulcéromutilantes non familiales des membres inférieurs, (à propos de 23 obseryations). Presse Méd.65, 2127–2132 (1957)
Campbell, A. M. G.: Hereditary sensory neuropathy. In: Handbook of clinical neurology. P. J. Vinken, G. W. Bruyn, eds., Vol. VIII, pp. 180–186. Amsterdam: North-Holland 1970
Denny-Brown, D.: Hereditary sensory radicular neuropathy. J. Neurol. Neurosurg. Psychiatry14, 237–252 (1951)
Dyck, P. J.: Histologic measurement and fine structure of biopsied sural nerve: normal and in peroneal muscular atrophy, hypertrophic neuropathy and congenital sensory neuropathy. Mayo Clin. Proc.41, 742–774 (1966)
Dyck, P. J., Ohta, M.: Neuronal atrophy and degeneration predominantly affecting peripheral sensory neurons. In: Peripheral neuropathy. P. J. Dyck, P. K. Thomas, E. H. Lambert, eds. Vol. II, pp. 791–824. London: Saunders 1975
Fardeau, M., Tome, F., Guimaraes, A., Cabello, a.: Rôle de la microscopie électronique en pathologie nerveuse périphérique. Arch. Anat. Pathol. (Paris) (à paraître)
Jedrzejowska, H., Milczarek, H.: Recessive hereditary sensory neuropathy. J. Neurol. Sci.29, 371–387 (1976)
Miller, R. G., Nielsen, S. L., Summer, A. J.: Hereditary sensory neuropathy and tonic pupils. Neurology (Minneap.)26, 931–935 (1976)
Mussini, J.-M., Vanderkellen, B., Hauw, J. J., Escourolle, R.: Etude quantitative du nerf périphérique sur coupes semi-fines par la technique du contraste interférentiel de Nomarski. Rev. Neurol. (Paris)133, 101–107 (1977)
Ohta, M., Ellefson, R. D., Lambert, E. H., Dyck, P. J.: Hereditary sensory neuropathy, type II: clinical, electrophysiologic, histologic and biochemical Studies of a Quebeck kindship. Arch. Neurol.29, 23–27 (1973)
Schoene, W. C., Asbury, A. K., Åström, K. K., Masters, R.: Hereditary sensory neuropathy. A clinical and ultrastructural study. J. Neurol. Sci.11, 436–487 (1970)
Vallat, J.: Communication personnelle
Vallat, J., Julien, J., Vital, C., Mouton, L.: Neuropathie sensitive héréditaire (2 observations). Etude ultrastructurale des nerfs périphériques. A paraître
Thevenard, A.: L'acropathie ulcéro-mutilante familiale. Rev. Neurol. (Paris)74, 193–210 (1942)
Vignon, G., Megard, M., Marin, A.: Une observation anatomoclinique d'acropathie ulcéro-mutilante. Presse Méd.64, 1954–1956 (1956)
Author information
Authors and Affiliations
Additional information
Pirages à part: Pr. R. Escourolle (Adresse susnommé)
Rights and permissions
About this article
Cite this article
Guimaraes, A., Hauw, J.J. & Escourolle, R. Etude quantitative et en microscopie electronique du nerf dans sept cas de neuropathie sensitive idiopathique sporadique. Acta Neuropathol 46, 133–137 (1979). https://doi.org/10.1007/BF00684814
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00684814