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Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus

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Summary

Several cationic amphiphilic drugs, each of which is known to induce generalized lipidosis in rats, were compared with respect to their cytological effects on rat choroid plexus epithelium. Chloroquine induced large cytoplasmic vacuoles, whereas the other drugs (quinacrine, 4,4′-diethylaminoethoxyhexestrol, chlorphentermine, iprindole, 1-chloro-amitriptyline, clomipramine) caused formation of lamellated or crystalloid inclusions as usually seen in drug-induced lipidosis. The ultrastructure of the chloroquine-induced vacuoles suggested storage of water-soluble materials (polar lipids and/or non-lipid materials) in addition to non-water-soluble polar lipids.

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Authors and Affiliations

  1. Department of Anatomy, University of Kiel, Olshausenstraße, D-2300, Kiel, Germany

    W. Frisch & R. Lüllmann-Rauch

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  1. W. Frisch
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  2. R. Lüllmann-Rauch
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Dedicated to Professor Dr. Helmut Leonhardt on the occasion of his 60th birthday

Supported by the Deutsche Forschungsgemeinschaft (Lu 172/3)

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Frisch, W., Lüllmann-Rauch, R. Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus. Acta Neuropathol 46, 203–208 (1979). https://doi.org/10.1007/BF00690845

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  • DOI: https://doi.org/10.1007/BF00690845

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