Summary
A desmoplastic primary cerebral neuroblastoma originating in the frontal lobe of a boy who died at the age of 6 years contained dense core vesicles within the cytoplasm of neoplastic cells as evidence of neuronal differentiation. Sarcomatous transformation had occurred at the time of recurrence. At autopsy, he also had cerebrospinal and extraneural metastases.
This is a preview of subscription content, log in via an institution to check access.
References
Azzarelli B, Richards DE, Anton AH, Roessmann U (1977) Central neuroblastoma. Electron microscopic observations and catecholamine determinations. J Neuropathol Exp Neurol 36:384–397
Henriquez AS, Robertson DM, Marshall WJS (1973) Primary neuroblastoma of the central nervous system with spontaneous extracranial metastases. J Neurosurg 38:226–231
Horten BC, Rubinstein LJ (1976) Primary cerebral neuroblastoma. A clinicopathological study of 35 cases. Brain 99:735–756
Peters A, Palay SL, Webster H de F (1976) The fine structure of the nervous system: the neurons and supporting cells. Saunders, Philadelphia London Toronto, pp 34–36
Rhodes RH, Davis RL, Kassel SH, Clague BH (1978) Primary cerebral neuroblastoma: a light and electron microscopic study. Acta Neuropathol (Berl) 41:119–124
Russell DS, Rubinstein LJ (1977) Pathology of tumours of the nervous system, 4th edn. Arnold, London
Shin W-Y, Laufer H, Lee Y-Ch, Aftalion B, Hirano A, Zimmerman HM (1978) Fine structure of a cerebellar neuroblastoma. Acta Neuropathol (Berl) 42:11–13
Yagishita S, Itoh Y, Chiba Y, Yuda K (1978) Cerebral neuroblastoma. Virchows Arch [Pathol Anat] 381:1–11
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goldammer, D., Goebel, H.H. Dense core vesicles in the desmoplastic variant of cerebral neuroblastoma. Acta Neuropathol 50, 81–83 (1980). https://doi.org/10.1007/BF00688540
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00688540