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Myelin changes in leprous neuropathy

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Summary

Myelin changes were observed in fibres of nerves from cases of leprosy. The myelin had a ‘loosened’ appearance caused by increased and irregular separation of the intraperiod line. ‘Loosening’ might affect all, or only some, of the lamellae forming a myelin sheath. There was a pathcy distribution of fibres with abnormal myelin, and they were seen only in nerves showing other marked pathological changes including the presence of oedema. The appearances are suggestive of intramyelinic oedema which may be related to the presence of endoneurial oedema.

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Authors and Affiliations

  1. Department of Neuropathology, Institute of Neurology, Queen Square, WC1N 3BG, London, UK

    J. M. Jacobs

  2. The Foundation for Medical Research, Worli, Bombay, India

    V. P. Shetty & N. H. Antia

Authors
  1. J. M. Jacobs
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  2. V. P. Shetty
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  3. N. H. Antia
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Additional information

Supported by the Brain Research Trust and the British Council, who funded an exchange arrangement between the Institute of Neurology, London and the Foundation for Medical Research (FMR), Bombay

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Jacobs, J.M., Shetty, V.P. & Antia, N.H. Myelin changes in leprous neuropathy. Acta Neuropathol 74, 75–80 (1987). https://doi.org/10.1007/BF00688341

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  • DOI: https://doi.org/10.1007/BF00688341

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