Summary
Four human neuroblastoma cell lines exhibited differences in their ability to differentiate into neuron-like cells in response to three different treatments, serum deprivation, or additions of dibutyryl cyclic-AMP or retinoic acid. Expression of N-myc gene product was reduced in neuroblastoma cell line SK-N-DZ differentiated by retinoic acid as compared with untreated cells. On the contrary, expression of c-src gene product, pp60c-src, was considerably enhanced in differentiated SK-N-DZ cells. Tyrosine phosphorylation of several cellular proteins was found to be enhanced in differentiated cells. Alteration in expression of these proto-oncogene products might be important in the differentiation of neuroblastoma cells into neuron-like cells.
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Supported in part by Grants-in-aid for Cancer Research (63015039, 63-16) from the Ministry of Education, Science and Culture, and the Ministry of Health and Welfare of Japan
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Matsumoto, M., Akiyama, T., Miyatake, S. et al. Expression of proto-oncogene products during drug-induced differentiation of a neuroblastoma cell line SK-N-DZ. Acta Neuropathol 79, 217–221 (1989). https://doi.org/10.1007/BF00294382
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DOI: https://doi.org/10.1007/BF00294382