Summary
This report presents the clinical, morphological and biochemical findings on an 11-month-old female Siamese cat with neurovisceral sphingomyelinosis. Gross pathological features and histochemical findings are compared with the human disease counterpart and the previously described animal models. Hepatomegaly was observed while splenomegaly was not. Although sphingomyelin in liver and spleen was biochemically elevated, histochemical results in this case were slightly different from those previously recorded in human and feline Niemann-Pick disease. These results suggest that this feline case might be a different type of animal Niemann-Pick disease to that reported previously.
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References
Adachi M, Tasai CY, Hoffman LM (1976) Animal model: mouse Niemann-Pick disease. Am J Pathol 85:229–231
Baker HJ, Reynolds GD, Walkley SU, Cox NR, Baker GH (1979) The gangliosidoses: comparative features and research. Vet Pathol 16:635–649
Baker HJ, Wood PA, Wenger DA, Walkley SU, Inui K, Kudoh T, Rattazzi MC, Riddle BL (1987) Sphingomyelin lipidosis in a cat. Vet Pathol 24:386–391
Bundza A, Lowden JA, Charlton KM (1979) Niemann-Pick disease in a Poodle dog. Vet Pathol 16:530–538
Elleder M, Jirásek A (1981) Neuropathology of various types of Niemann-Pick disease. Act Neuropathol [Suppl] (Berl) VII:201–203
Lake BD (1984) Lysosomal enzyme deficiencies. In: Adams JH, Corsellis JAN, Duchen LW (eds) Greenfield's neuropathology, 4th edn. Edward Arnold, London, pp 491–572
Luna LG (1968) Manual of histologic staining methods of the armed forces institute of pathology, 3rd edn. McGraw-Hill, New York, pp 140–173
Percy DH, Jortner BS (1971) Feline lipidosis. Arch Pathol 92:136–144
Snyder SP, Kingston RS, Wenger DA (1982) Niemann-Pick disease: sphingomyelinosis of Siamese cats. Am J Pathol 108:252–254
Suzuki K (1985) Congenital metabolic disorder. In: Iijima S, Ishikawa H, Kageyama K, Shimamine T (eds) Current encyclopedia of pathology, 23A. Nakayama, Tokyo, pp 331–381 (in Japanese)
Wenger DA; Sattler M, Kudoh T (1980) Niemann-Pick disease: a genetic model in Siamese cats. Science 208:1471–1473
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Yamagami, T., Umeda, M., Kamiya, S. et al. Neurovisceral sphingomyelinosis in a Siamese cat. Acta Neuropathol 79, 330–332 (1989). https://doi.org/10.1007/BF00294670
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DOI: https://doi.org/10.1007/BF00294670