Summary
Two cases of postoperative hypoxic-ischemic encephalopathy are described in which Betz cells of the primary motor area were selectively spared. In one patient the hypoxic-ischemic encephalopathy led to a vegetative state and in the other patient to a spastic quadriparesis and cortical blindness. In contrast to the relative sparing of Betz cells, Purkinje cells of the cerebellar cortex were totally destroyed. These two cases suggest that Betz cells are relatively resistant to hypoxic-ischemic insult under certain conditions.
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References
Brierley JB, Graham DI (1984) Hypoxia and vascular disorders of the central nervous system. In: Adams JH, Corsellis JAN, Duchen LW (eds) Greenfield's neuropathology, 4th edn. Adward Arnold, London, pp 125–207
Holmes G (1909) The pathology of amytrophic lateral sclerosis. Rev Neurol Psychiatry 8:693–724
Hsu SM, Raine L, Fanger H (1981) A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. Am J Clin Pathol 75:734–738
Mori H, Kondo J, Ihara Y (1987) Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 235:1641–1644
Murayama S, Bouldin TW, Suzuki K (1990) Immunocytochemical study of primary motor area in motor neuron disease (abstract). J Neuropathol Exp Neurol 48:331
Pappolla MA, Omar R, Saran B (1989) The “normal” brain. “Abnormal” ubiquitinilated deposits highlight an age-related protein change. Am J Pathol 135:585–591
Steegmann AT (1968) The neuropathology of cardiac arrest. In: Minckler J (ed) Pathology of the nervous system. McGraw-Hill, New York, pp 1005–1029
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Murayama, S., Bouldin, T.W. & Suzuki, K. Selective sparing of Betz cells in primary motor area in hypoxic-ischemic encephalopathy. Acta Neuropathol 80, 560–562 (1990). https://doi.org/10.1007/BF00294620
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DOI: https://doi.org/10.1007/BF00294620