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Expression of stress-response (heat-shock) protein 27 in human brain tumors: an immunohistochemical study

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Summary

This report concerns the expression of the low molecular weight stress-response (heat-shock) protein 27 (srp 27) in a variety of human brain tumors. Immunohistochemical techniques were used; cells of the breast cancer line MCF7 served as positive controls. The reaction product was found exclusively in the cytoplasm. Srp 27 was detected in 5/5 breast tumor metastases to the brain and in 5/21 meningiomas. The protein was also detected in 5/11 glioblastomas and 2/5 pituitary adenomas. By comparison, positive staining was observed in only 1/15 astrocytomas and 1/7 medulloblastoma and no reaction was seen with the oligodendrogliomas, schwannomas and gangliogliomas tested. These observations demonstrate that srp 27 is expressed by certain primary intracranial tumors.

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Authors and Affiliations

  1. Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA

    M. Kato & F. Herz

  2. Division of Neuropathology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, 10467, Bronx, NY, USA

    S. Kato & A. Hirano

Authors
  1. M. Kato
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  2. F. Herz
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  3. S. Kato
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  4. A. Hirano
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Kato, M., Herz, F., Kato, S. et al. Expression of stress-response (heat-shock) protein 27 in human brain tumors: an immunohistochemical study. Acta Neuropathol 83, 420–422 (1992). https://doi.org/10.1007/BF00713535

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  • DOI: https://doi.org/10.1007/BF00713535

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