Summary
Using immunological techniques urinary hCG, pregnancy-specific ß-glycoprotein (SP1) and ß-subunit of hCG (ß-hCG) levels were measured in the serum and cerebrospinal fluid of patients with trophoblastic tumours. After removal of hydatidiform moles, urinary hCG, ß-hCG and SP1 levels were similar, but SP1 levels tended to exceed serum ß-hCG levels. SP1 usually disappeared first. In patients with metastatic choriocarcinoma, SP1 levels appeared to be lower than ß-hCG values in serum and cerebrospinal fluid, but urinary hCG, ß-hCG and SP1 concentrations all decreased during chemotherapy. Measurements of SP1 levels may well be useful in the monitoring of patients being treated for trophoblastic tumours.
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Supported by the grants from Cancer Center of Tokyo Medical College and Ministry of Health and Welfare of Japan for research on handicapped children and trophoblastic disease
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Soma, H., Kikuchi, K., Takayama, M. et al. Concentrations of SP1 and ß-hCG in serum and cerebrospinal fluid and concentrations of hCG in urine in patients with trophoblastic tumour. Arch. Gynecol. 230, 321–327 (1981). https://doi.org/10.1007/BF02199681
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DOI: https://doi.org/10.1007/BF02199681