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Anti-androgen-therapy in pachydermia of the female larynx — a new therapeutic possibility

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Summary

Case-report about a 56 year old white female patient with pachydermia laryngis and hirsutism, successfully treated with cyproterone-acetate, a testosterone antagonist. The significance of androgenic hormones for the development of epithelial changes in the female larynx is emphasized. The administration of antiandrogenic substances as a new therapeutic measure is discussed.

Zusammenfassung

Es wird über eine 56jährige Patientin mit Pachydermia laryngis und Hirsutismus berichtet, die erfolgreich mit dem Testosteron-Antagonisten Cyproteronacetat behandelt werden konnte. An Hand dieses Falles wird die Bedeutung androgener Hormone für die Genese von Epithelveränderungen am weiblichen Kehlkopf unterstrichen und die Anwendung antiandrogener Substanzen als neuartige therapeutische Möglichkeit diskutiert.

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Authors and Affiliations

  1. Department of otolaryngology and the Institute of Experimental Pathology, University of Innsbruck, Fritz-Pregel-Straße 3, A-6020, Innsbruck, Austria

    K. Loewit, B. Hussl, E. Richter & S. Schwarz

Authors
  1. K. Loewit
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  2. B. Hussl
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  3. E. Richter
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  4. S. Schwarz
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Additional information

We are indebted to the Schering-Wien Ges.m.b.H. for supplying samples of Androcur®. The skilful technical assistance of Miss Margit Buchmann and Miss Margit Leinmüller is gratefully acknowledged. Histological examinations of biopsy specimens were performed at the Department of Pathology (Head: Prof. Dr. A. Propst), University of Innsbruck, Medical School.

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Loewit, K., Hussl, B., Richter, E. et al. Anti-androgen-therapy in pachydermia of the female larynx — a new therapeutic possibility. Arch Otorhinolaryngol 215, 75–79 (1977). https://doi.org/10.1007/BF00463194

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  • DOI: https://doi.org/10.1007/BF00463194

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