Ergebnisse und Erfahrungen in der Kombinationsbehandlung von fortgeschrittenen ORL-Tumoren mit Chemo- und Strahlentherapie unter besonderer Berücksichtigung von 5-FU

Summary

The report covers the results of 71 patients with advanced inoperable ORL-tumors and recurrences treated since 1972 after so-called partial synchronisation with 5-FU. Most patients were treated with 5-FU. Recently the highly differentiated keratinizing squamous cell carcinomas are treated with Bleomycin. Patients rejecting cytostatic longtime infusion with 5-FU — necessary for partial synchronisation due to 5-FU — have been treated with Vincristin. The combined therapy with 5-FU (1 g) followed by irradiation as well as Vincristin (0.5 mg) and Bleomycin (2×7.5 mg) were tolerated by minimal complications and insignificant side-effects. The breakdown of survival rates according to the tumor localization shows the best 5 year survival times of patients with laryngeal carcinomas (advanced tumors respectively recurrences). This combined therapy leeding to a prolongation of live with a supportable feeling seems to be an ingenious supplement of therapeutical methods in advanced ORL-tumors.