Summary
We studied the complex relationship between nasal polyposis and ASA (acetylsalicylic acid) intolerance in 154 patients with nasal polyps. The clinical histories of all patients were reviewed, and diagnostic tests for immune or allergic causes and the responsiveness of patients to challenges with ASA-substitutive drugs were analyzed. A third of our patients tested were found to have positive personal histories of atopy and 35% showed ASA intolerance. Although 40% had bronchial asthma, only 16.8% of all patients had positive tests for allergy. We were unable to find a specific mechanism to explain the relationship between nasal polyposis and ASA intolerance and further investigations are still required.
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Blackwell GJ, Flower RJ, Vane JR (1975) Some characteristics of the prostaglandin synthetizing system in rabbit kidney microsomes. Biochim Biophys Acta 398:178–190
Blumstein GI, Tuff L (1957) Allergy treatment in recurrent nasal polyposis: its importance and value. Am J Med Sci 234:269–272
Carlin I, Haynes JT, Spain J (1971) Are nasal polyps an allergic phenomenon? Ann Allergy 29:631–634
Cauna N, Hinderer KB, M-Anzetti GW, Swanson EW (1972) Fine structure of nasal polyps. Ann Otol Rhinol Laryngol 81:41–58
Delaney JC (1976) Aspirin idiosyncrasy in patients admitted for nasal polypectomy. Clin Otolaryngol 1:27–32
De Weck AL (1971) Immunological effects of aspirin anhydride, a contaminant of commercial acetylsalicylic acid preparations. Int Arch Allergy Immunol 41:393–418
Migind N (1981) Allergie nasali. Liviana, Padova
Patriarca G, Venuti A, Schiavino D (1972) Dermatophagoides Pteronyssinus e allergia alle polveri della casa. Osservazioni in pazienti affetti da asma bronchiale. Riforma Med 86:2166–7171
Patriarca G, Venuti A, Schiavino D, Fais G (1976) Intolerance to aspirin. Clinical and immunological studies. Z Immunitaetsforsch 151:295–304
Patriarca G, Venuti A, Schiavino D, Romano A, Fais G (1978) Clinical, immunological and biochemical aspects of the syndromes due to intolerance to acetyl-salicylic acid (ASA). In: Ricci M, Fauci AS, Arcangeli P, Torzuoli O (eds) Developments in clinical immunology. Academic Press, London, pp 231–239
Patriarca G, Venuti A, Schiavino D, Romano A, Fais G, Di Rienzo V (1980) La sindrome da intolleranza polimedicamentosa. Recenti Prog Med 68:21–33
Patrono C, Schiavino D, Ciabattoni G, Venuti A, Pugliese F, Patriarca G (1978) Aspirin-intolerance: unaltered susceptibility of platelet cyclo-oxigenase to inhibition by aspirin in vitro. J Allergy Clin Immunol 62:271–275
Samter M, Beers RF (1967) Concerning the nature of intolerance to aspirin. J Allergy 40:281–293
Schiavino D, Venuti A, Romano A, Fais G, De Salvo V, Patriarca G (1982) In vivo and in vitro diagnosis of Aspirin intolerance. Acta Med Rom 19:187–191
Settipane GA, Chafee FH (1977) Nasal polyps in asthma and rhinitis. A review of 6,037 patients. J Allergy Clin Immunol 59:17–21
Wälti M, De Weck AL (1984) Immunologic studies on Aspirin. Annual Meeting of the European Academy of Allergology and Clinical Immunology, Brussels 1984. Abstracts, p 159
Whiteside TL, Rabin BS, Zetterberg J, Criep L (1975) The presence of IgE on the surface of lymphocytes in nasal polyps. J Allergy Clin Immunol 55:186–194
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Patriarca, G., Romano, A., Schiavino, D. et al. ASA disease: the clinical relationship of nasal polyposis to ASA intolerance. Arch Otorhinolaryngol 243, 16–19 (1986). https://doi.org/10.1007/BF00457900
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DOI: https://doi.org/10.1007/BF00457900