Abstract
A study was undertaken to evaluate the incidence of nasopharyngeal α-streptococci with inhibitory activity against pathogens, as a defense mechanism of the normal bacterial flora against infection. Cultures were taken from the nasopharynges of 43 children with otitis media with effusion (OME). The detection rates of α-streptococci with inhibitory activity against Haemophilus influenzae, Streptococcus pneumoniae, Staphylococus aureus and group A streptococci were significantly lower in the nasopharynx than those isolated from the tonsils of the same patients. Moreover, the detection rates of α-streptococci with inhibitory activity against all of these pathogens derived from the nasopharynx were lower than those in healthy children, streptococcal strains with activity against H. influenzae and Strep. pneumoniae were also lower than that in patients with tonsillitis. These findings suggest that low nasopharyngeal levels of α-streptococci with inhibitory activity against respiratory pathogens may render children susceptible to OME. Further studies are needed to investigate the relationships between the prevalence of pathogens in the nasopharynx and the inhibitory activities of α-streptococci against them in order to devise and select optimal treatment for patients with OME.
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References
Alhady RA, Shanoubi ME (1984) Tympanometric findings in patients with adenoid hyperplasia, chronic sinusitis and tonsillitis. J Laryngol Otol 98:671–676
Bernstein JM, Dryja DM, Loos BG, Dickinson DP (1989) Restriction fragment mapping of nontypable Haemophilus inluenzae: a new tool to study this middle ear pathogen. Otolaryngol Head Neck Surg 100: 200–206
Brook I, Yocum P, Shah K, Feldman B, Epstein S (1983) Aerobic and anaerobic bacteriologic features of serous otitis media in children. Am J Otolaryngol 4:389–392
Dajani AS, Tom MC, Law DJ (1976) Viridans, bacteriocins of alpha-haemolytic streptococci. Isolation, characterization, and partial purification. Antimicrob Agents Chemother 9:81–88
Diamond C, Sisson PR, Kearns AM, Ingham HR (1989) Bacteriology of chronic otitis media with effusion. J Laryngol Otol 103:369–371
Draper W (1967) Secretory otitis media in children. A study of 540 children. Laryngoscope 77:636–653
Giebink GS, Mills EL, Huff JS, Edleman CK, Weber ML, Juhn SK, Quie PG (1967) Microbiology of serous and mucoid otitis media. Pediatrics 63:915–919
Sanders CC, Sanders WE (1982) Enocin: antibiotic produced by Streptococcus salivarius that may contribute to protection against infection due to group A streptococci. J Infect Dis 146: 683–690
Sanders CC, Nelson GE, Sanders WE Jr (1977) Bacterial interference. Epidemiological determinants of the antagonistic activity of the normal throat flora against group A streptococci. Infect Immun 16:599–603
Sanders WE (1969) Bacterial interference. Its occurrence among the respiratory tract flora and characterization of inhibition of group A streptococci. J Infect Dis 120: 698–707
Silverstein H, Miller GF, Linderman RC (1966) Eustachian tube dysfunction as a cause for chronic secretory otitis in children. Laryngoscope 76:259–273
Sprunt K, Redman W (1968) Evidence suggesting importance of role of interbacterial inhibition in maintaining balance of normal flora. Ann Intern Med 68:578–590
Stenfors LE, Raisanen S (1984) The bacterial flora of the nasopharynx, with special reference to middle ear pathogens. Acta Otolaryngol (Stockh) 108:122–125
Stenfors LE, Raisanen S (1990) Occurrence of middle ear pathogens in the nasopharynx of young individuals. Acta Otolaryngol (Stockh) 109:142–148
Stenfors LE, Raisanen S (1991) Is attachment of bacteria to the epithelial cells of the nasopharynx the key to otitis media? Int J Pediatr Otorhinolaryngol 22:1–8
Stenfors LE, Råisånen (1992) Bacterial attachment in vivo to epithelial cells of the nasopharynx during otitis media with effusion. J Laryngol Otol 106:111–115
Tos M, Bak-Pedersen K (1972) The pathogenesis of chronic secretory otitis media. Arch Otolaryngol 95:511–521
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Fujimori, I., Hisamatsu, K., Kikushima, K. et al. The nasopharyngeal bacterial flora in children with otitis media with effusion. Eur Arch Otorhinolaryngol 253, 260–263 (1996). https://doi.org/10.1007/BF00171139
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DOI: https://doi.org/10.1007/BF00171139